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You are here:Home-Antibody Drug Conjugates-ADC Cytotoxin

Request The Product List ofADC Cytotoxin ADC Cytotoxin

ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.

The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.

Cat. No. Product Name CAS No. Information
H9339

Nendratareotide Uzatansine

 		1853254-97-3

Nendratareotide Uzatansine is a Somatostatin receptor 2 (SSTR2)-targeting cytotoxic conjugate with an IC50 of 10 nM.
H9335

Locnartecan

 		1472614-83-7

Locnartecan is a potential agent for controlling early stage tumor growth for non-small cell lung cancer (NSCLC). PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor, SN-38.
H9316

ANG-1005

 		1075214-55-9

ANG1005 is a novel taxane derivative, consists of three paclitaxel molecules covalently linked to Angiopep-2, designed to cross the blood–brain and blood–cerebrospinal barriers and to penetrate malignant cells via LRP1 transport system.
H8800

Clezutoclax

 		1949843-71-3

Clezutoclax is a novel preparation of Bcl-​xL inhibitory compounds having low cell permeability and antibody drug conjugates.
H8799

Deruxtecan

 		1599440-13-7

Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
H8565

McMMAF

 		863971-19-1

Mafodotin is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery. MMAF is a potent antimitotic and antitublin auristatin derivative with a charged C-terminal phenylalanine residue that attenuates its cytotoxic activity compared to its uncharged counterpart, MMAE.
H8404

MMAF-OMe

 		863971-12-4

An antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells; an ADC payload.
H8403

MMAD hydrochloride

 		173441-26-4

A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).
H8402

Ansamitocin P-3

 		66547-09-9

A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation; inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice.
H8401

Maytansinol

 		57103-68-1

Maytansinol (Ansamitocin P-0) is a microtubule assembly inhibitor; ADC payload in development of antibody drug conjugates.

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