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You are here:Home-Inhibitors & Agonists-Autophagy-Autophagy

Request The Product List ofAutophagy Autophagy

    Autophagy is a conserved cellular degradation and recycling process in the lysosome. In mammalian cells, there are three primary types of autophagy: microautophagy, macroautophagy, and chaperone-mediated autophagy (CMA). Microphagy captures cargoes by means of invaginations or protrusions of the lysosomal membrane directly, CMA uses chaperones to identify cargo proteins and then unfolds and transfers them into the lysosomal, while macroautophagy sequesters cargo by autophagosomes-de novo synthesized of double-membrane vesicles-and subsequently transport it to the lysosome.


    Macroautophagy is the best studied and it occurs at a low level constitutively and can also be further induced under stress conditions, such as nutrient or energy starvation with a salient feature of autophagy protein degradation. Stress-induced macrophagy plays an important role in protein catabolism with another key protein degradation pathway, the ubiquitin–proteasome system (UPS).


    As the study progressed, autophagy gains its importance under basal, nutrient-rich conditions, and is now recognized as a critical housekeeping pathway in catabolism of diverse cellular constituents, such as protein aggregates (aggrephagy), lipid droplets (lipophagy), iron complex (Ferritinophagy) and carbohydrate. Except for macromolecules, autophagy can also target several organelles and structures, such as mitochondria (mitophagy), peroxisome (pexophagy), endoplasmic reticulum (reticulophagy or ER-phagy), ribosome (ribophagy), spermatozoon-inherited organelles following fertilization (allophagy), secretory granules within pancreatic cells (zymophagy) and intracellular pathogens (xenophagy).Autophagy and its dysfunction are associated with a variety of human pathologies, including ageing, cancer, neurodegenerative disease, heart disease and metabolic diseases, such as diabetes. Plenty of drugs and natural products are involved in autophagy modulation through multiple signaling pathways. Small molecules that can regulate autophagy seem to have great potential to intervene such diseases in animal models or clinical courses.

Cat. No. Product Name CAS No. Information
H9341

Ninerafaxstat

 		2254741-41-6

Ninerafaxstat is a potent 3-ketoacyl-CoA thiolase inhibitor.
H9270

Dehydroascorbic acid

 		490-83-5

Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.
H9241

B355252

 		1261576-81-1

B355252 is a novel small molecule, confers neuroprotection against cobalt chloride toxicity In mouse hippocampal cells through altering mitochondrial dynamics and limiting autophagy induction
H9034

SIRT3 activator MA

 		2241761-55-5

SIRT3 activator MA is a novel SIRT3 activator that induces MCF-7 cell autophagy,with pronounced antiproliferative activity achieved by enhancing autophagy.
H8974

Udonitrectag

 		1458063-04-1

Udonitrectag is a potent treatment of neurotrophic keratitis to drugs.
H6670

S29434

 		874484-20-5

S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1; inhibits QR2-mediated ROS production within the 100 nM range in various cell types, including hepatoma HepG2 cells, the astroglial cell line U373 and primary dopaminergic neurons; S29434 (S 29434) is fairly stable in vivo.
H6613

PFK15

 		4382-63-2

PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO; does not inhibit PFK-1, hexokinase, phosphoglucose isomerase and PFKFB4, and has no activity against a panel of 96 kinases; inhibits cancer cell viability (H522 cell IC50=0.72 uM) and induces apoptosis, suppresses the glucose uptake and exhibits antitumor effects in human xenograft models.
H6612

PFK-158

 		1462249-75-7

The first competitive small molecule inhibitor of PFKFB3; more potent than 3PO with improved PK properties; glycolysis inhibitor.
H8578

THZ-P1-2

 		2058075-45-7

THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines.
H8567

AUTAC1

AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2.

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