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You are here:Home-Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-PGC-1α

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Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) serves as an inducible coregulator in the control of energy homeostasis. PGC-1α is a powerful transcriptional coregulator of GLUT4 and mitochondrial genes, including components of the electron transport system. PGC-1α is expressed abundantly in tissues with high energy demand, including brown adipose tissue, heart, skeletal muscle, kidney, and brain. PGC-1α has been shown to regulate adaptive thermogenesis, mitochondrial biogenesis, glucose and fatty acid metabolism, the peripheral circadian clock, fiber-type switching in skeletal muscle, and heart development. PGC-1α, a critical booster of mitochondrial function, is an excellent candidate for preventing insulin resistance and metabolic syndromes secondary to mitochondrial dysfunction. PGC-1α has been shown to influence energy metabolism.

Cat. No. Product Name CAS No. Information
H5882

ZLN-005

 		49671-76-3

A novel small molecule PGC-1α transcriptional activator; increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity in L6 myotubes; produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice.
H5881

SR 18292

 		2095432-55-4

SR 18292 (SR18292) is a potent PGC-1α acetylation activator that is similar to C-80, increases PGC-1α acetylation, suppresses gluconeogenic gene expression, and reduce glucose production in hepatocytes; increases the interaction of PGC-1α with GCN5 and reduces transcriptional activity of HNF4α; reduces fasting blood glucose, increases hepatic insulin sensitivity, and improves glucose homeostasis in diabetic mice.
H5880

PGC-1α activator C80

 		154191-98-7

PGC-1α activator C80 is a potent PGC-1α acetylation activator with AC50 of 3.1 uM, induces Pck1 and G6pc expression with AC50 of 11.9 uM and 12.8 uM, reduces glucose production in hepatocytes.

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