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You are here:Home-Research Areas-Other Indications-Fibrosis

Request The Product List ofFibrosis Fibrosis

Fibrosis is defined by the deposition of pathological fibrillar collagen, inflammatory cells, loss of capillaries, and dedifferentiation of epithelial cells.

Fibrosis occurs as a part of normal wound healing. However, excessive or dysregulated fibrosis can lead to severe organ dysfunction and is a feature of a variety of diseases. Due to its insidious onset, fibrosis tends to go undetected in its early stages. This is in part why these diseases remain so poorly understood. Animal models have provided a means to examine these early stages and to isolate and understand the effect of perturbations in signaling pathways, chemokines, and cytokines. Here, we summarize recent progress in the understanding of the molecular pathogenesis of fibrosis, both its initiation and its maintenance phases, from animal models of fibrosis in the skin and liver. Due to these organs’ properties, modeling fibrosis in them poses unique challenges. Elegant solutions have therefore been developed for modeling fibrosis in each, and now, great potential for animal models to contribute to our understanding appears scientifically imminent.

Cat. No. Product Name CAS No. Information
H9546

Cudetaxestat

 		1782070-21-6

Cudetaxestat (BLD-0409) is a potent and orally active autotaxin (ATX) inhibitor.
H8983

Amcipatricin

 		143483-67-4

Amcipatricin is a potent cell membrane permeability enhancers.
H8961

Posenacaftor

 		2095064-05-2

Posenacaftor is a potent,an orally Cystic fibrosis transmembrane regulator (CFTR) protein modulator.
H8958

Nesolicaftor

 		1953130-87-4

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier, a type of CFTR modulator that increases the amount of CFTR proteins a cell makes.
H8947

Icenticaftor

 		1334546-77-8

Icenticaftor is a potent,an orally cystic fibrosis transmembrane conductance regulator (CFTR) protein, with EC50 value of 0.076 μM.
H8939

Exaluren disulfate

 		2244622-33-9

Exaluren disulfate is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). ELX-02 is being developed as a therapy for genetic diseases caused by nonsense mutations.
H8938

ELX-02

 		1375073-94-1

ELX-02 is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). ELX-02 is being developed as a therapy for genetic diseases caused by nonsense mutations.
H8937

Exaluren

 		1375073-93-0

Exaluren is an investigational, advanced synthetic eukaryotic ribosome selective glycoside (ERSG). Exaluren is being developed as a therapy for genetic diseases caused by nonsense mutations.
H8855

Pelabresib

 		1380087-89-7

Pelabresib(CPI-0610)is a potent, selective, and cell-active BET inhibitor. CPI-0610 inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC.
H8819

Dirocaftor

 		2137932-23-9

Dirocaftor is a potent therapeutic agent for cystic fibrosis caused by the mutation of a cystic fibrosis transmembrane conductance regulator (CFTR) serving as a type of chloride channel.

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