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You are here:Home-Inhibitors & Agonists-Immunology/Inflammation-T Cell Receptor (TCR)

Request The Product List ofT Cell Receptor (TCR) T Cell Receptor (TCR)

Cat. No. Product Name CAS No. Information
H4100

HXJ 42

 		1428640-39-4

A PP1 analog that has greater selectivity and potency for Zap-70(AS) over wild-type Zap-70, as assessed by Erk and Lat phosphorylation, as well as by proliferative responses of mature CD4+ cells; effectively rescues Zap70(AS) OT-I cells from negative selection.
H4099

AX-024 hydrochloride

 		1704801-24-0

A potent, orally available inhibitor of TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with IC50 of 1 nM; inhibits phosphorylation of ZAP70 at Tyr319 and of CD3ζ at Tyr142; inhibits TCR triggering-induced gene expression (1093 genes), including genes that are relevant for inflammatory T cell responses (cytokines IL-17A, IL-2, IL-6R and IL-18R1); attenuates the severity of skin inflammation in a psoriasis model as well as of lung inflammation in an asthma model.
H4098

AX-024

 		1370544-73-2

A potent, orally available inhibitor of TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with IC50 of 1 nM; inhibits phosphorylation of ZAP70 at Tyr319 and of CD3ζ at Tyr142; inhibits TCR triggering-induced gene expression (1093 genes), including genes that are relevant for inflammatory T cell responses (cytokines IL-17A, IL-2, IL-6R and IL-18R1); attenuates the severity of skin inflammation in a psoriasis model as well as of lung inflammation in an asthma model.
H4097

AX-000

 		340014-88-2

A hit compound that inhibits the proliferation of human peripheral blood T cells stimulated with anti-CD3 with IC50 of

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