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You are here:Home-Research Areas-Neurological Disease-Sleep Disorder

Request The Product List ofSleep Disorder Sleep Disorder

Sleep is characterized by altered consciousness, it is split into two distinct stages- rapid eye movement (REM) and non-REM. The circadian clock controls the pattern of sleep and wakefulness. It is regulated by the light levels, temperature, metabolites, neurotransmitters, neuropeptides, and neurohormones, which cause a daily fluctuation in expression levels of many sleep-related genes.

Cat. No. Product Name CAS No. Information
H9584

Posovolone

 		256955-84-7

Posovolone (Co 134444) is an orally active sedative-hypnotic neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects.
H9369

GSK189254A

 		720690-73-3

GSK189254A (GSK189254) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
H9351

Sunobinop

 		1126793-40-5

Sunobinop is a novel,oral, highly potent and selective partial agonist for nociceptin/orphanin-FQ peptide (NOP) receptors.
H8814

Danavorexton

 		2114324-48-8

Danavorexton is potent G protein-​coupled receptors (GPCRs) having extracellular loops from a first GPCR and intracellular loops from a second GPCR.
H4552

Solriamfetol hydrochloride

 		178429-62-4

Solriamfetol hydrochloride (JZP-110, R-228060, ADX-N05, YKP-10A)?is a norepinephrine-dopamine reuptake inhibitor that inhibits dopamine and norepinephrine transporter with IC50 of 2.9 and 4.4 uM, respectively; a wake-promoting agent with dopaminergic and noradrenergic activity.
H4391

Lorediplon

 		917393-39-6

A partial positive allosteric GABAA receptor modulator; displays activity at the alpha1-subunit, associated with promoting sleep.
H4387

Indiplon

 		325715-02-4

A potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively); potentiates the GABA-activated chloride current in recombinant GABA(A) receptors in a dose-dependent and reversible manner in 293 cells, 10-fold selective for α1 subunit-containing receptors over GABA(A) receptors containing α2, α3, or α5 subunits.

H4385

GR3027

 		2089238-18-4

GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC; inhibits α1β2γ2L receptor 29 ± 5% of THDOC enhancement of the GABA response, does not antagonize the effect of GABA at the GABAA receptor; during the specific conditions used for the different receptors, IC50=250 nM for the α1β2γ2L GABAA receptor and 350 nM for the α5β3γ2L GABAA receptor; restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.
H4295

Atagabalin

 		223445-75-8

Atagabalin (PD 0200390) is a novel ligand of the voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) for treatment for insomnia.
H3760

Suvorexant

 		1030377-33-3

A potent, CNS penetrant, orally available, dual orexin receptor antagonist with Ki of 0.55 and 0.35 nM for OX1R and OX2R, respectively; significantly and dose-dependently reduces locomotor activity and promotes sleep in rats.

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