| Cat. No. |
Product Name |
CAS No. |
Information |
| H4367 |
Verdinexor
|
1392136-43-4 |
Verdinexor (KPT-335, KPT335) is an orally bioavailable, selective inhibitor of nuclear export (SINE), inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1) and the viability of Jurkat and canine DLBCL cells with IC50 of 8.7 nM and 13.3 nM, respectively; induces apoptosis in CLBL1 cells and primary canine DLBCL cells; reduces influenza a virus replication in vitro and in vivo; also inhibits XPO1-mediated transport and reduces RSV replication in vitro, shows effectivity against RSV A and B strains and reduces viral replication following prophylactic or therapeutic administration. |
| H1448 |
Zanamivir
|
139110-80-8 |
Zanamivir is a hihly potent, broad-spetrum influenza viral neuraminidase (NA) inhibitor with IC50 of 0.95 nM and 2.7 nM for influenza A and B, respectively; inhibits plaque formation by laboratory-passaged strains of influenza A and B viruses,IC50 ranging from 0.005 to 0.014 uM; interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions. |
| H1442 |
Pimodivir
|
1629869-44-8 |
Pimodivir (VX-787, JNJ872, JNJ 63623872) is a first-in-class, orally bioavailable inhibitor of influenza virus polymerase PB2 subunit with Kd of <3 nM, CPE EC50 of 2 nM; shows strong potency versus multiple influenza A strains, including pandemic 2009 H1N1 and avian H5N1 flu strains with mean CPE EC50 of <2 nM; Pimodivir (VX-787) is highly efficacious in both prophylaxis and treatment models of mouse influenza and is superior to the neuraminidase inhibitor Oseltamivir.l |
| H1441 |
Peramivir trihydrate
|
1041434-82-5 |
Peramivir (RWJ-270201, BCX-1812) is an inhibitor of influenza neuraminidase that prevents new viral particles from being released; an antiviral agent used to treat and prevent influenza A and influenza B. |
| H1440 |
Peramivir
|
330600-85-6 |
Peramivir (RWJ-270201, BCX-1812) is an inhibitor of influenza neuraminidase that prevents new viral particles from being released; an antiviral agent used to treat and prevent influenza A and influenza B. |
| H1439 |
Oseltamivir phosphate
|
204255-11-8 |
A competitive inhibitor of influenza neuraminidase that prevents new viral particles from being released; an antiviral agent used to treat and prevent influenza A and influenza B. |
| H1437 |
Nucleozin
|
341001-38-5 |
A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation; inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069 uM, 0.16 uM and 0.33 uM in PRA, respectively; protects mice challenged with lethal doses of avian influenza A H5N1; also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection. |
| H1434 |
Laninamivir
|
203120-46-1 |
Laninamivir (CS-8958) is a prodrug of the influenza neuraminidase (NA) inhibitor R-125489, shows long-acting anti-influenza virus activity. |
| H1432 |
Favipiravir
|
259793-96-9 |
Favipiravir (T705) is a pyrazinecarboxamide derivative that is active against influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses; shows potent inhibitory activity against influenza A, B, and C viruses, with IC50s of 0.013 to 0.48 ug/ml. |
| H1430 |
Baloxavir Marboxil
|
1985606-14-1 |
Baloxavir Marboxil (S-033188, Xofluza) is the prodrug of Baloxavir acid (S-033447) that potently and selectively inhibits the cap-dependent endonuclease within the polymerase PA subunit of influenza A and B viruses. |
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