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You are here:Home-Inhibitors & Agonists-Cell Cycle/DNA Damage-Topoisomerase

Request The Product List ofTopoisomerase Topoisomerase

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.

Cat. No. Product Name CAS No. Information
H9038

(S)-Erypoegin K

 		2055053-90-0

(S)-Erypoegin K is an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase IIα: Induction of G2 phase arrest in human gastric cancer cells.The IC50 of (S)-Erypoegin K for apoptotic cell death of HL-60 cells was 90 nM, which was much lower than many other antitumor drugs.
H8615

Pyrazoloacridine

 		99009-20-8

Pyrazoloacridine (NSC 366140) is an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment.
H8381

Merbarone

 		97534-21-9

Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage. Merbarone is an anticancer agent.
H2298

XR-5000

 		89459-25-6

XR-5000 (Acridine Carboxamide) is an inhibitor of topoisomerase I and II for treatment of various types of cancers.
H2297

Voreloxin

 		175414-77-4

A first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II; exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.
H2296

SW-044248

 		522650-83-5

SW-044248 is a novel selective inhibitor of Topoisomerase I; inhibits Top I differently from camptothecin; selectively toxic for some NSCLC cell lines.
H2295

Indotecan

 		915303-09-2

Indotecan (LMP400) is an anticancer DNA Topoisomerase I (Top1) inhibitor.
H2294

Indimitecan

 		915360-05-3

Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor.
H2292

Idarubicin hydrochloride

 		57852-57-0

An anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells; inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM; also induces histone eviction from chromatin.
H2291

Idarubicin

 		58957-92-9

Idarubicin (4-Demethoxydaunorubicin;IMI-30;NSC 256439) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells; inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM; also induces histone eviction from chromatin.

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