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You are here:Home-Inhibitors & Agonists-Membrane Transporter/Ion Channel-TRP Channel

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TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

Cat. No. Product Name CAS No. Information
H9619

JW-65

 		2763378-71-6

JW-65 (JW65) is a selective, potent,CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3;JW-65 shows similar potency and selectivity on TRPC3 channels, but is metabolically much more stable than its precursor, demonstrated by its much longer half-life (>4 h) in mouse, rat, and human liver microsomes when compared to Pyr3.JW-65 treated mice showed substantially decreased susceptibility to PTZ-induced seizures in a dose-dependent manner.
H9577

Motugivatrep

 		920332-28-1

Motugivatrep is the potent antagonist of transient receptor potential type 1 (TRPV1). Motugivatrep has a wide range of usefulness in treating drugs, urine tabletops, and respiratory diseases .
H9462

Evifacotrep

 		2413739-88-3

Evifacotrep is a potent short transient receptor potential channel 5 (TRPC5) inhibitor with IC50 value of less than or equal to 50 nM.

H9334

Libvatrep

 		871814-52-7

Libvatrep is a potent vanilloid receptor TRPV1 antagonist.
H9064

KPR-2579

 		1801742-41-5

KPR-2579 is a novel Transient receptor potential melastatin 8 (TRPM8) antagonist with IC50 value of 0.08 µM.
H8917

Vocacapsaicin

 		1931116-86-7

Vocacapsaicin is a first-in-class non-opioid therapeutic that rapidly converts to capsaicin, a potent TRPV1-agonist;CA-008 provides long-lasting pain relief after a single, local injection by selectively desensitizing pain-conducting nerve fibers, without producing numbness or weakness.
H8684

BI-749327

 		2361241-23-6

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.
H4896

WS-12

 		68489-09-8

A potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent; displays higher potency and efficacy compared to menthol (EC50=193 uM), does activates thermo-sensitive TRP ion channel including TRPV1, TRPV2, TRPV3, TRPV4 and TRPA1 at 1 mM; accelerates skin permeability barrier recovery, also reduces epidermal proliferation associated with barrier disruption.
H4895

V-116517

 		1073616-61-1

V-116517 is a novel potent, selective, oral bioavailable TRPV1 antagonist with IC50 of 35.1 nM; shows high selectivity for TRPV1 over TRPV3 and TRPV4 (>10 uM) in a panel of 66 ion channels, receptors, transporters; dose-dependently reverses thermal hyperalgesia with ED50 of 2 mg/kg (p.o.) in acute inflammatory CFA model; shows excellent aqueous solubility, metabolic stability, oral bioavailability in multiple species, and excellent efficacy in a variety of animal pain models.
H4894

TRPM8 antagonist 14

 		259674-19-6

TRPM8 antagonist 14 is a potent, selective TRPM8 antagonist with IC50 of 0.2 nM in calcium influx assays, shows no activity on TRPV1; shows significant target coverage in both an icilin-induced WDS (at 1-30 mg/kg s.c.) and oxaliplatin-induced cold allodynia (at 0.1-1 μg s.c.) mice models.

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