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You are here:Home-Research Areas-Inflammation/Autoimmune Disease-Dermatitis

Request The Product List ofDermatitis Dermatitis

   Dermatitis is irritation or inflammation of the skin. There are many types of dermatitis. Some, such as diaper rash, are characterized by itchy red skin on a specific area of the body. Others involve blisters or breakouts that resemble acne. Dandruff is considered a mild form of dermatitis that affects the scalp. Because most types of dermatitis have a distinctive appearance, they often can be diagnosed based on a physical exam, although other testing, such as patch testing to determine if a specific allergen is to blame for dermatitis, sometimes is necessary. Treatment for dermatitis depends on the type and includes measures to relieve dry skin, itching, and other symptoms.


  Types:

~Allergic contact dermatitis     ~Irritant contact dermatitis


~Atopic dermatitis                    ~Stasis dermatitis 


~Diaper dermatitis                     ~Dyshidrotic dermatitis

 

~Nummular dermatitis               ~ Seborrheic dermatitis


~Autosensitization dermatitis      ~Perioral dermatitis


Cat. No. Product Name CAS No. Information
H9597

PF-07038124

 		2415085-44-6

PF-07038124, is an effective PDE4 inhibitor;It only requires a very low dose to strongly inhibit the expression of IL-13, IL-4, and IL-23 in patients with atopic dermatitis and psoriasis.
H8849

Lazucirnon

 		1251528-23-0

Lazucirnon is a potent Pharmaceutical formulations CCR3 antagonists.
H5444

PF 5212372

 		916136-25-9

PF 5212372 (PLA-950, ZPL-521, ZPL 5212372) is a potent, selective inhibitor of cPLA2 (cytosolic phospholipase A2α) with IC50 of 7 nM; inhibits PGD2 and cysteinyl leukotriene release from anti-IgE-stimulated human lung mast cells with IC50 of 0.29 and 0.45 nM, respectively; inhibits ionomycin-stimulated release of leukotriene B(4), thromboxane A(2), and PGD(2) (IC50 2.6, 2.6, and 4.0 nM, respectively); significantly inhibits AMP-induced contraction of human bronchi.
H5365

Lotamilast

 		947620-48-6

Lotamilast (RVT 501, E6005) is a?potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM; produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application; ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.
H5349

Difamilast

 		937782-05-3

Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM).?
H5329

AN-2728

 		906673-24-3

A potent PDE4 inhibitor with IC50 of 0.49 uM; also shows inhibition against PDE1A3, PDE3Cat, and PDE7A1; suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.
H4844

Asivatrep

 		1005168-10-4

Asivatrep (PAC-14028) is a potent, selective TRPV1 antagonist with IC50 of 55 nM against capsaicin-induced Ca2+ influx in rat DRG neurons, does not inhibit or activate other TRP channels such as hTRPV2, hTRPV3, hTRPM8 and hTRPA1; inhibits capsaicin-evoked calcium influx in keratinocytes at sub-micromolar concentrations, blocks capsaicin-induced blood perfusion increase, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice, also attenuates dermatitis-associated barrier damages in Df and OXZ models.
H4175

PF-04965842

 		1622902-68-4

PF-04965842 (Abrocitinib, PF04965842) is a potent, selective, orally bioavailable JAK1 inhibitor with IC50 of 29 nM; exhibits good selective inhibition profile for JAK1 versus other JAK family enzymes (IC50=803/>10,000/1250 nM for JAK2/JAK3/TYK2, respectively); demonstrates efficacy in a rat adjuvant-induced arthritis (rAIA) model.
H3421

PF-3893787

 		943057-12-3

PF-3893787 (ZPL 3893787) is a potent and selective H4 receptor antagonist with binding Ki of 2.4 nM; has an IC50 of 1.16 nM on human native isolated eosinophils assessing actin polymerisation; exhibits anti-inflammatory activity.

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