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You are here:Home-PROTACs-E3 Ligase Ligand

Request The Product List ofE3 Ligase Ligand E3 Ligase Ligand

The PROTAC molecule consists of a ligand, which binds an E3 ubiquitin ligase, connected by a linker to another ligand that binds the target protein.

The association between a protein and an E3 ligase, as induced by a PROTAC molecule, will lead to the transfer of ubiquitin and degradation of the targeted protein.

Cat. No. Product Name CAS No. Information
H9460

Eragidomide

 		1860875-51-9

Eragidomide(CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. CC-90009 coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation.
H9210

Lenalidomide-I

 		2207541-30-6

Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570.
H9209

CRBN modulator-1

 		2407829-65-4

CRBN modulator-1 is a Thalidomide analog and a CRBN modulator , compound 10, has an IC50 of 3.5 μM and a Ki of 0.98 μM.
H9208

Thalidomide-NH-CH2-COOH

 		927670-97-1

Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032.
H9197

TD-106

 		2250288-69-6

TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation.
H7182

VHL-IN-15

 		1360616-29-0

VHL-IN-15 is a potent (IC50=4.1 uM) von Hippel–Lindau protein (VHL) ligand that disrupts the VHL/HIF-1α interaction.
H8444

E3 Ligase Ligand 2

 		5054-59-1

An E3 ligase ligand for PROTAC.
H8443

E3 Ligase Ligand 3

 		1061605-21-7

An E3 ligase ligand for PROTAC.
H8442

VHL Ligand 3

 		1448189-98-7

A VHL ligand for PROTAC.
H8441

VHL-2

 		1631137-31-9

A VHL ligand for PROTAC.

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