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You are here:Home-Inhibitors & Agonists-Cytoskeleton/Cell Adhesion Molecules-Ezrin

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Cat. No. Product Name CAS No. Information
H2315

NSC668394

 		382605-72-3

NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM; inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels, inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM; inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.
H2314

NSC-305787 hydrochloride

 		53868-26-1

A small molecule inhibitor of Ezrin with Kd of 5.85 uM; inhibits ezrin phosphorylation, ezrin-actin interaction and ezrin-mediated motility of osteosarcoma (OS) cells in culture; inhibits lung metastasis of ezrin-sensitive cells in mice; also inhibits SHIP-1 and SHIP-2.
H2313

NSC-305787

 		785718-37-8

A small molecule inhibitor of Ezrin with Kd of 5.85 uM; inhibits ezrin phosphorylation, ezrin-actin interaction and ezrin-mediated motility of osteosarcoma (OS) cells in culture; inhibits lung metastasis of ezrin-sensitive cells in mice; also inhibits SHIP-1 and SHIP-2.
H2312

MMV-667492

 		380877-02-1

MMV-667492 (MMV 667492, MMV667492)?is a novel potent Ezrin inhibitor with Kd of 29.4 nM; exhibits potent anti-ezrin activity in all biologic assays and has better physicochemical properties for drug-likeness than NSC305787; a novel antimetastatic agent for the treatment of metastatic osteosarcoma.

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