Cat. No. | Product Name | CAS No. | Information |
---|---|---|---|
H5764 |
K-7174 dihydrochloride |
191089-60-8 | A selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2); suppresses the expression of AR, including ARVs, in 22Rv1 cells, exertes potent anticancer activity against GATA2+/AR+ PC cell lines in vitro; induces transcriptional repression of class I histone deacetylases (HDAC1, -2, and -3) via caspase-8-dependent degradation of Sp1; significantly decreases HAMP expression, also upregulates CEBPB. |
H5763 |
K-7174 |
191089-59-5 | A selctive small molecule inhibitor of the transcription factor GATA-binding protein 2 (GATA2); suppresses the expression of AR, including ARVs, in 22Rv1 cells, exertes potent anticancer activity against GATA2+/AR+ PC cell lines in vitro; induces transcriptional repression of class I histone deacetylases (HDAC1, -2, and -3) via caspase-8-dependent degradation of Sp1; significantly decreases HAMP expression, also upregulates CEBPB. |
H5762 |
GATA4-IN-3 |
544681-96-1 | A novel small molecule that inhibits GATA4/NKX2-5 transcriptional synergy with IC50 of 3 uM, with no activity on the protein kinases involved in the regulation of GATA4 phosphorylation; also inhibits the ET-1-stimulated BNP gene expression, and inhibits hypertrophic growth in a cardiomyocyte hypertrophy model, without effect on apoptotic cell death. |
H5761 |
GATA4 activator 7 |
878090-53-0 | A novel small molecule that activates GATA4/NKX2-5 transcriptional synergy with EC50 of 7 uM in cell reporter assay. |
H5760 |
3i-1000 |
544681-96-1 |
3i-1000 is a potent, small molecule inhibitor of GATA4-NKX2-5 interaction, inhibits GATA4-NKX2-5 transcriptional synergy with IC50 of 3 uM; inhibits cardiac gene expression induced by mechanical stretch and phenylephrine, such as ANP and BNP, without significantly influencing the baseline mRNA levels, inhibits hypertrophic process in cardiomyocytes in vitro; significantly inhibits PE-induced elevation in GATA4 Ser-105 phosphorylation in neonatal rat cardiomyocytes; promotes myocardial repair in experimental model of myocardial ischemia reperfusion injury. |
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