| Cat. No. |
Product Name |
CAS No. |
Information |
| H9252 |
SC-43
|
1400989-25-4 |
SC-43 is a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist; SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects. |
| H9251 |
Angoline hydrochloride
|
1071676-04-4 |
Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM; Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. |
| H9250 |
Angoline
|
21080-31-9 |
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM; Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. |
| H9212 |
W2014-R
|
2473028-69-0 |
W2014-R is a novel STAT3 inhibitor,While surface plasmon resonance (SPR) analysis suggested that W2014-R may have similar affinities with STAT3 protein. W2014-R bind to wild-type STAT3, with KD of 3.39 μM respectively. |
| H9211 |
W2014-S
|
2473028-71-4 |
W2014-S is a novel STAT3 inhibitor,While surface plasmon resonance (SPR) analysis suggested that W2014-S may have similar affinities with STAT3 protein. W2014-S bind to wild-type STAT3, with KD of 3.64 μM respectively;W2014-S regresses human non-small cell lung cancer xenografts and sensitizes EGFR-TKI acquired resistance.W2014-S showed stronger inhibition than W2014-R on cell proliferation and colony survival, especially in A549 cell line. |
| H9163 |
Stafia-1
|
|
Stafia-1 is a potent STAT5a inhibitor (Ki=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members. |
| H4277 |
XZH-5
|
1360562-98-6 |
XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes; inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin, demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration; blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ. |
| H4276 |
UC-514321
|
299420-83-0 |
UC-514321 is a more effective analog of NSC-370284 that directly binds to STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo; shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent. |
| H4275 |
STAT5b inhibitor 7
|
1818390-58-7 |
STAT5b inhibitor 7 (Capstafin prodrug) is the pivaloyloxymethyl ester prodrug of Capstafin, which is a potent, selective STAT5b inhibitor with Ki of 0.34 uM; inhibits STAT5b with selectivity over STAT5a in human tumor cells, inhibits cell viability and induces apoptosis in human tumor cells in a STAT5-dependent manner. |
| H4274 |
STAT5-IN-1
|
285986-31-4 |
A selective, small molecule inhibitor of the transcription factor STAT5 with IC50 of 47¡À17 uM in FP assays; shows little to no inhibition for STAT1, STAT3 and Lck (
|
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