| Cat. No. |
Product Name |
CAS No. |
Information |
| H1202 |
ZIKV inhibitor K22
|
2141978-86-9 |
ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i); inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s
|
| H1201 |
VGTI-A3-03
|
|
VGTI-A3-03 is a novel potent, highly virus-specific inhibitor of DENV replication with greatest activity against DENV serotype 2 (IC50=25 nM), directly bind DENV capsid protein; also demonstrates some inhibitory activity against DENV1, DENV4, and WNV; does not inhibit viral RNA replication or secretion of viral particles, significantly diminishe secreted particles in treated cells, the binding pocket in the capsid molecule is at the dimerization interface; VGTI-A3-03 is incorporated into virus particles released from infected cells. |
| H1200 |
ST-148
|
400863-77-6 |
ST-148 a novel potent, broad-spetrum inhibitor of dengue virus (DENV) replication, inhibits DENV-2 wth EC50 of 16 nM in viral titer reduction assays, interacts with the DENV Capsid protein; exhibits a broad range of potencies with EC50 of 0.512, 1.150, and 2.832 uM for DENV-3, -4, and -1, respectively; significantly reduced viremia and viral load in vital organs and tended to lower cytokine levels in the plasma in a nonlethal model of DENV infection in AG129 mice. |
| H1199 |
SFV785
|
1188497-23-5 |
SFV785 (SRPIN-785) is a derivative of SRPIN340 that selectively inhibits NTRK1 and MAPKAPK5 kinase, shows anti-viral activity on HCV, DENV and yellow fever viruses; inhibits DENV propagation without inhibiting DENV RNA synthesis or translation, inhibits the recruitment and encapsulation of the nucleocapsid in specific ER compartments during the DENV assembly process. |
| H1198 |
MK-0608
|
443642-29-3 |
MK-0608 is a nucleoside analogue that shows potent inhibition for replication of several mosquito-borne flaviviruses including DENV and ZIKV; also inhibits viral RNA replication in the subgenomic HCV genotype 1b replicon with EC50 of 0.3 uM, inhibits ZIKV viral polymerase both in vitro and in vivo. |
| H1197 |
JNJ-1A
|
|
JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM, in the absence of cytotoxicity; shows equipotent antiviral activity against DENV serotypes 1, 2, and 4, induces mutation T108I in non-structural protein 4B (NS4B) in in vitro resistance selection experiments. |
| H1196 |
JBJ-16-111
|
|
JBJ-16-111 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E. |
| H1195 |
JBJ-01-162-04
|
2313524-77-3 |
JBJ-01-162-04 is a small molecule targeting the flavivirus E protein with broad-spectrum activity, shows activity against DENV in the infectivity assay with IC90 of 0.1 uM; binds to DENV2 E protein (sE2) with Kd of 1.4 uM, reduces DENV viral burden in vivo. |
| H1194 |
IHVR-19029
|
1447464-73-4 |
IHVR-19029 is a novel antiviral compound that acts as ER α-glucosidase inhibitor, synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells combined with favipiravir (T-705); significantly increases the survival rate of infected animals in mouse model of Ebola virus infection. |
| H1193 |
GS-5734
|
1809249-37-3 |
GS-5734 (Remdesivir) is a?monophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140 nM) and other filoviruses (EC50=0.019-1.48 uM) in cell-based assays; suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers. |
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