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Request The Product List ofPrion Prion

Prions virus, like viruses, are filterable, infectious, pathogenic and host specific. The structure of prion particles was not observed under electron microscope, and there was no immune effect, interferon production and interference. The biggest threat of prion to human beings is that it can cause human and livestock to suffer from degenerative diseases of the central nervous system and eventually die without treatment. Therefore, the world health organization regards prion and AIDS as the most dangerous diseases in the century.

Cat. No. Product Name CAS No. Information
H1499

IND125

A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum; prolongs the lives of mice expressing a chimeric human/mouse PrP transgene inoculated with Creutzfeldt-Jakob disease prions.
H1498

IND-114338

 		1426259-35-9

A novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc.
H1497

DAPH-12

 		145915-63-5

DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM); combinations of DAPH-12 and EGCG more effectively inhibits spontaneous and seeds NM fibrillization, and more effectively eliminates NM4 and NM25 than either small molecule alone.
H1496

DAPH-1

 		145915-58-8

DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture; inhibits prion nucleation by preventing both Head-to-Head and Tail-to-Tail intermolecular interactions; also is a potent and selective inhibitor of EGFR kinase with IC50 of 1 uM, selectively inhibits both ligand-induced EGF-R and p185c-erbB2 autophosphorylation and c-fos mRNA induction.
H1495

Anle-138b

 		882697-00-9

Emrusolmin is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn); strongly inhibits all prion strains tested including BSE-derived and human prions; binds to aggregated tau and inhibits tau aggregation in vitro and in vivo. has no detectable toxicity, excellent oral bioavailability and blood-brain-barrier penetration.

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