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You are here:Home-Inhibitors & Agonists-Immunology/Inflammation-Cyclooxygenase (COX)

Request The Product List ofCyclooxygenase (COX) Cyclooxygenase (COX)

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

Cat. No. Product Name CAS No. Information
H9405

(R)-Enflicoxib

 		251443-65-9

(R)-Enflicoxib is a novel,selective cyclo-oxygenase 2(COX-2) inhibitor.
H9404

(S)-Enflicoxib

 		251443-66-0

(S)-Enflicoxib is a novel cyclo-oxygenase 2 inhibitor.
H9342

Ocarocoxib

 		215122-22-8

Ocarocoxib is a potent COX-​2 (cyclooxygenase-​2) inhibitor,a non-steroidal anti-inflammatory.
H9242

CAY10404

 		340267-36-9

CAY10404 is a potent and highly selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM;CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM). CAY10404 is a potent inhibitor of PKB/Akt and MAPK signaling pathways and induces apoptosis in NSCLC cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities.
H8935

Enflicoxib

 		251442-94-1

Enflicoxib is a potent cyclo-oxygenase 2 inhibitor with IC50  of  2.93 μM.
H8768

Otenaproxesul

 		1000700-29-7

Otenaproxesul an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2) ATB-346 possesses antiinflammatory and antinociceptive activities
H3980

Vitacoxib

 		1374128-90-1

A potent, selective COX-2 inhibitor with IC50 of 0.34 ug/mL, >50-fold selectivity over COX-1 (IC50=19.4 ug/mL); a novel nonsteroidal anti-inflammatory drugs for veterinary use.
H3979

Tilmacoxib

 		180200-68-4

Tilmacoxib (JTE-522) is a potent, selective inhibitor of cyclooxygenase-2 (COX-2) that inhibits human recombinant COX-2 with IC50 of 85 nM, dispalys no activity against COX-1 (IC50>100 uM); significantly inhibits fibrosis, also inhibits growth of pulmonary metastases of colorectal cancer in rats.
H3978

SC-236

 		170569-86-5

SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM; displays >1,700-fold selectivity over COX-1 (IC50=17.8 uM); exhibits anti-inflammatory properties and potent antimetastatic activity both in vitro and in vivo.
H3977

Rofecoxib

 		162011-90-7

A potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells; displays 1,000-fold selectivity over COX-1 activity; selectively inhibits LPS-induced, COX-2-derived PGE(2) synthesis after blood coagulation (IC50=0.53 uM); exhibits anti-inflammation activity in osteoarthritis and rheumatoid arthritis rodent models.

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