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You are here:Home-Inhibitors & Agonists-Cell Cycle/DNA Damage-DNA Alkylator/Crosslinker

Request The Product List ofDNA Alkylator/Crosslinker DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Cat. No. Product Name CAS No. Information
H9337

Mipicoledine

 		942149-56-6

Mipicoledine is a potent DNA alkylating agent potentially for the treatment of brain cancer.
H9298

Ecubectedin

 		2248127-53-7

Ecubectedin is a potent antibody drug conjugates comprising ecteinascidin derivatives for use in therapy of diseases such as cancers.
H8743

Imifoplatin

 		1339960-28-9

Imifoplatin is a kind of phosphorus platinum compound, which can be used in the treatment of bone cancer
H8519

PIP-199

 		622795-76-0

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM). PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics.
H8373

Phosphoramide mustard

 		10159-53-2

Phosphoramide mustard is the major metabolite for Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response.
H2054

Trabectedin

 		114899-77-3

Trabectedin (Ecteinascidin-743, ET-743, Ecteinascidin)?is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata that shows remarkably anticancer activity in a variety of in vitro and in vivo systems; a DNA minor groove, guanine-specific alkylating agent; shows hign potency against ovarian carcinoma xenografts.
H2053

Thio-TEPA

 		52-24-4

An alkylating agent used to treat cancer that has been previously used in the palliation of a wide variety of neoplastic diseases.
H2052

Temozolomide

 		85622-93-1

An alkylating agent used as a treatment of some brain cancers, astrocytoma and glioblastoma; a prodrug and an imidazotetrazine derivative of the alkylating agent dacarbazine.
H2051

Satraplatin

 		129580-63-8

Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis; shows similar cytotoxicity and pattern of cytotoxicity to cisplatin against human ovarian carcinoma cell lines (IC50=1.7 uM); shows antitumor selectivity far superior to cisplatin, carboplatin, or tetraplatin in vivo; orally active.
H2050

Oxaliplatin

 		61825-94-3

A platinum-based antineoplastic agent that works by blocking the duplication of DNA; forms both inter- and intra-strand cross links in DNA, prevents DNA replication and transcription, causing cell death.

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