| Cat. No. |
Product Name |
CAS No. |
Information |
| H6618 |
PIN1 inhibitor VS10
|
920849-78-1 |
PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM, displays >2-fold more potency than ATRA; reduces cancer cell viability of ovarian cancer cell lines with IC50 of 53.9-76.4 uM; targets PIN1 to the proteasome, and induces PIN1 protein degradation in NIH3T3 fibroblasts, also shows inhibitory effects on PIN1 target proteins (cyclin D1, pSer473-Akt and β-catenin) in the OVCAR3 cell line. |
| H6617 |
Pin1 inhibitor API-1
|
680622-70-2 |
Pin1 inhibitor API-1 (API-1) is a potent, specific inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) and inhibits Pin1 cis-trans isomerizing activity with IC50 of 72.3 nM, displays remarkable selectivity over other peptidyl-prolyl cis-trans isomerases, including Pin4, FKBP12, and cyclophilin A; suppresses in vitro cell proliferation and migration of HCC cells with low IC50 values, which is depended on both Pin1 expression and XPO5 phosphorylation; recognizes and isomerizes the phosphorylated serine-proline motif of phosphorylated XPO5 and passivates phosphorylated XPO5, maintains the active pXPO5 conformation, rescues the pre-miRNA loading of pXPO5 and increases mature miRNA biogenesis; suppresses tumour growth in mice. |
| H8364 |
NSC 141562 Bromide
|
1029089-56-2 |
A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis; strongly inhibits mature miR-155 generation in a timedependent manner in U87 and primary GBM cells, reduces the proliferation, migration and invasion, increases the expression of PCDH9 and PCDH7, decreases the expression of mesenchymal transition-associated markers, N-cadherin, vimentin, MMP9 and β-catenin. |
| H2817 |
Targaprimir-96
|
1655508-14-7 |
A small molecule that selectively modulates miR-96 production in cancer cells and triggers apoptosis; directly engages pri-miR-96 in breast cancer cells, and has a favorable pharmacokinetic profile and decreases tumor burden in a mouse model of triple-negative breast cancer. |
| H2816 |
SID-3712249
|
522606-67-3 |
SID 3712249 is a small molecule inhibitor of the biogenesis of microRNA-544 (miR-544); causes apoptosis in triple negative breast cancer cell; bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α and ATM transcripts. |
| H2815 |
NSC 141562
|
1029221-71-3 |
A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis; strongly inhibits mature miR-155 generation in a timedependent manner in U87 and primary GBM cells, reduces the proliferation, migration and invasion, increases the expression of PCDH9 and PCDH7, decreases the expression of mesenchymal transition-associated markers, N-cadherin, vimentin, MMP9 and β-catenin. |
| H2814 |
myomiRs-IN-1
|
1392224-59-7 |
myomiRs-IN-1 is a small-molecule probe that selectively inhibits myogenic microRNAs (myomiRs) including miR-1, miR-133a, and miR-206; upregulates miR-221/222 level and suppresses myoD protein expression in C2C12 cells; inhibits the differentiation of C2C12 cells. |
| H2813 |
miR544-IN-1
|
522606-67-3 |
miR544-IN-1 (SID 3712249) is a selective small molecule inhibitor of miR-544 biogenesis; selectively inhibits production of the mature microRNA, sensitizes cells to 5-fluorouracil, and derepresses mRNAs affected by miR-544 in cellulo and in vivo, including boosting mTOR expression; reverses a tumor cell's physiological response to hypoxia. |
| H2811 |
miR-21 inhibitor 37
|
2241028-18-0 |
miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122; miR-21 inhibitor 37 has no effect on either mature or primary miR-21 levels in HeLa cells, as well as no effect on miR-21 transcription; exhibits low micromolar potency against different established cancer cells (MCF-7 and MIA PaCa-2, IC50=4.5 and 6.7 uM); shows significant rescue of both PDCD4 (9.5-fold increase) and PTEN (1.5-fold increase) levels in A498 RCC cells, sensitizes cells to topotecan-induced apoptosis. |
| H2810 |
BzDANP
|
1994258-88-6 |
BzDANP is a small molecule modulator of pre-miR-29a maturation by Dicer, effectively stabilizes the C-bulged RNA and suppresses Dicer-mediated processing of pre-miR-29a in a concentration dependent manner. |
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