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Request The Product List ofRhinovirus Rhinovirus

Rhinoviruses(RV) are members of the genus Enterovirus of the family Picornaviridae and are classified into three species (A, B, and C). More than 160 RV types have been identified to date.25 Rhinoviruses are responsible for most upper respiratory tract infections (common colds) and, after RSV, are the viruses most often detected in wheezing infants. For years it was assumed that RV infection was confined to the upper airway and did not affect the chest except under unusual circumstances. Initial studies demonstrated optimal RV replication at 33–35 °C, and it was assumed that higher temperatures in the lower airways would limit RV replication. Contrary to these initial assumptions, direct measurements in the lower airways have shown that large and medium size airways are at the ideal temperature for RV replication.26 Furthermore, some RV types, including C-species viruses, replicated equally well at 33 °C and 37 °C.27,28 In addition, cultured lower airway epithelial cells support RV replication in vitro at least as well as, and perhaps even better than, cells derived from the upper airways.29,30 Rhinovirus has been detected in sputum and bronchial biopsy specimens after experimental inoculation of the upper airway31–33 and is frequently detected in lower airway biopsies from infants with recurrent wheezing.34 These findings provide strong evidence that RV can infect the lower airways, especially in young children. The species of RV affects its virulence, because RV-A and RV-C cause more severe illnesses in infants  and are more likely to cause exacerbations of childhood asthma.


References:


1.Drysdale SB,et al. J Infect. 2017;74 Suppl 1:S41–S46.

Cat. No. Product Name CAS No. Information
H1505

WIN 52084

 		98102-61-5

An antiviral compound that inhibits attachment to cells, inhibits human rhinovirus type 14 (HRV14) replication.
H1504

Rupintrivir

 		223537-30-2

Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM; potently and irreversibly inhibits HRV 3C protease with an inactivation rate constant (kobs/[I]) of 1,470,000 ¡À 440,000 M-1 s-1 for HRV 14; also potently inhibits related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11.
H1503

Pleconaril

 		153168-05-9

Pleconaril (Picovir, VP-63843, Win-63843) is a broad spectrum antipicornaviral agent that inhibits rhinovirus replication by interaction with the VP1 protein; inhibits EV-D68 with EC50 of 430 nM; shows active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.
H1502

IMP-1088

 		2059148-82-0

IMP-1088 is a potent, selective human N-myristoyltransferase with IC50 of less than 1 nM for both HsNMT1 and HsNMT2, inhibits Rhinoviruses (RVs) capsid myristoylation in cells; pharmacological and rapidly inhibits host-cell N-myristoylation, potently and efficiently block RV replication (IC50=17 nM) without cytotoxicity; potently blocks a key step in viral capsid assembly, to deliver a low nanomolar antiviral activity against multiple RV strains, poliovirus and foot and-mouth disease virus, and protection of cells against virus-induced killing.
H1501

GC376

 		1416992-39-6

GC376 (GC-376) is a broad-spectrum antiviral agent that inhibits 3C or 3C-like proteases (3Cpro or 3CLpro) of picornaviruses, noroviruses, and coronaviruses with IC50 of 0.96 (MD145), 0.82 (TGEV) and 0.2 uM (HRV) in FRET protease assays; demonstrates significant effectivities against caliciviruses (NV and MNV-1), coronaviruses (TGEV, FIPV, MHV, 229E, and BCV), and picornaviruses (HRVs 18, 51, and 68 (EC50=0.3-1.5 uM), EV71 (EC50=10.3 uM), and PTV); showed promise in treating cats with certain presentations of feline infectious peritonitis.
H1500

Disoxaril

 		87495-31-6

A picornavirus replication inhibitor by binding to the hydrophobic pocket within the VP1 coat protein, thus stabilizing the virion and blocking its uncoating.

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