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You are here:Home-Inhibitors & Agonists-Others-AP2-associated Kinase 1 (AAK1)

Request The Product List ofAP2-associated Kinase 1 (AAK1) AP2-associated Kinase 1 (AAK1)

Cat. No. Product Name CAS No. Information
H6038

LP-935509

 		1454555-29-3

LP-935509 is a potent, selective and brain-penetrant adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 of 3.3 nM; inhibited μ2 protein phosphorylation in HEK293 cells overexpressing human AAK1 with IC50 of 2.8 nM; also potent inhibits closely related BIKE and GAK with IC50 of 14 nM and 320 nM, respectively in a panel of 389 kinases; reduces pain response in phase II formalin and reverses fully established pain behavior in vivo.
H6037

BMT-090605

 		1551403-51-0

BMT-090605 (BMT 090605, BMT090605)?is a potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50 0.6 nM; weakly inhibits BIKE and GAK with IC50 of 45 and 60 nM, respectively.
H6036

BMT-046091

 		1551401-20-7

BMT-046091 (BMT046091) is a potent and selective AAK1 inhibitor with IC50 of 2.8 nM; BMT-046091 is inactive in a panel of functional or binding assays for receptors, transporters and enzymes at >5 μM; [3H]BMT-046091 is a potent and selective radioligand to determine AAK1 distribution and target engagement.
H6035

BMS-901715

 		1699861-37-4

BMS-901715 (BMS901715) is a?potent, selective adapter protein-2 associated kinase 1 (AAK1) inhibitor.
H6034

AAK1 inhibitor 25A

AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1); displays selectivity over the other members of the subfamily, Numb-associated kinases GAK and STK16, in a TR-FRET binding displacement assay; binds to BMP2K in live HEK293T cells with an IC50 of 602 nM.
H6033

AAK1 inhibitor 1

 		2247894-32-0

AAK1 inhibitor 1 (SGC-AAK1-1) is a potent, selective inhibitor of AAK1 and BMP2K/BIKE ((BMP-2 inducible kinase)) that potently targets the ATP-binding site (AAK1 Ki =9.1 nM, BIKE Ki= 17 nM); disaplays excellent kinase selectivity, only three kinases (RIOK1 KD=72 nM, RIOK3 KD=290 nM, and PIP5K1C KD=260 nM) were observed to bind SGC-AAK1-1 within 30-fold of the KD of AAK1 in a KINOMEscan assay; has potency for ectopically expressed full-length AAK1- and BIKE-Nluc fusion proteins (AAK1 IC50=230 nM; BIKE IC50=1.5 uM)in a live cell NanoBRET assay.

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