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You are here:Home-Inhibitors & Agonists-GPCR-Glucagon Receptor

Request The Product List ofGlucagon Receptor Glucagon Receptor

Glucagon receptor is in the G protein-coupled receptor family, that is important in controlling blood glucose levels. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

Cat. No. Product Name CAS No. Information
H9496

LY3502970

 		2212020-52-3

LY3502970 is an orally active nonpeptide GLP-1R agonist.
H9295

Danuglipron tromethamine

 		2230198-03-3

Danuglipron tromethamine is a potent, orally bioavailable agonist of the glucagon-like peptide-1 receptor agonist (GLP-1R).
H9213

PF-06882961

 		2230198-02-2

PF-06882961 is a potent, orally bioavailable agonist of the glucagon-like peptide-1 receptor.
H9173

GLP-1(28-36)amide

 		1225021-13-5

GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP); GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide has anti-diabetic and cardioprotection effects.
H8985

Avexitide acetate

 		2051593-46-3

Avexitide acetate is a first in class glucagon like peptide-1 (GLP-1) receptor antagonist
H8984

Avexitide

 		133514-43-9

Avexitide is a first in class glucagon like peptide-1 (GLP-1) receptor antagonist
H8815

Dapiglutide

 		2296814-85-0

Dapiglutide is a potent GLP-1/GLP-2 receptor agonist.
H3350

Taspoglutide

 		275371-94-3

Taspoglutide is a glucagon-like peptide-1(GLP-1) agonist for treatment of type 2 diabetes; Phase III clinical trials halted due to incidences of side effects.
H3349

PF-06372222

 		1407592-99-7

A potent glucagon receptor (GCGR) negative allosteric modulator.
H3348

NNC-0640

 		307986-98-7

NNC-0640 (NNC 0640, NNC0640) is a potent, selective glucagon receptor (GCGR) negative allosteric modulator with IC50 of 69.2 nM; also inhibits a penel of mutant GCGRs with IC50 of 100-700 nM.

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