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You are here:Home-Research Areas-Endocrine Disorders-Sexual Dysfunction

Request The Product List ofSexual Dysfunction Sexual Dysfunction

Sexual function is a complex physiological process. The maintenance of normal sexual function depends on the cooperation of multiple systems of human body, which involves the coordination of nervous system, cardiovascular system, endocrine system and reproductive system. In addition, it must have good mental state and healthy psychology. When the above system or mental and psychological aspects have abnormal changes, it will affect the normal sexual life, affect the quality of sexual life, and show sexual dysfunction.

Sexual dysfunction is the disorder of sexual behavior and sexual sensation, which is often manifested as the abnormality or absence of sexual psychological and physiological response, and it is the general term of many different symptoms. According to statistics, 52% of men aged 40-70 have different degrees of sexual dysfunction. The incidence rate of female sexual dysfunction is also high. Some people think that it can account for 30% to 60% of adult women. Sexual desire and orgasm disorders are most common among them. Some women may never have orgasms in their lifetime.

Cat. No. Product Name CAS No. Information
H5713

Enclomiphene citrate

 		7599-79-3

Enclomiphene citrate((E)-Clomifene, cis-Clomifene, RMI-16289, ICI-46476)?is a nonsteroidal selective estrogen receptor modulator (SERM) that is under development for the treatment of male hypogonadism; inhibits the ER in the pituitary gland, reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, increases gonadotropin secretion and hence gonadal production of testosterone.
H5414

Udenafil

 		268203-93-6

A potent and selective phosphodiesterase 5 (PDE5) inhibitor for treat erectile dysfunction.
H5405

Tadalafil

 		171596-29-5

Tadalafil is a potent phosphodiesterase-5 (PDE5) inhibitor (IC50=1 nM); no inhibition on most of the other families of PDEs, with the exception of PDE11.
H5333

Avanafil

 		330784-47-9

A potent and highly selective PDE5 inhibitor (IC50=5.2 nM) for erectile dysfunction; shows no significant effect on PDE1, PDE6 and PDE11.
H3765

Cligosiban

 		900510-03-4

A potent, specific oxytocin receptor antagonist with Ki of 9.5 nM, displays high selectivity over the vasopressin receptors; demonstrates excellent potency and selectivity, as well as promising in vivo pharmacokinetics and significantly improved aqueous solubility.
H3567

PF-00446687 hydrochloride

 		862282-10-8

PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.
H3566

PF-00446687

 		862281-92-3

PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.
H3559

Bremelanotide acetate

 		1607799-13-2

Bremelanotide acetate is an analogue of the naturally occurring peptide alpha-MSH; melanocortin receptor agonist.
H3558

Bremelanotide

 		189691-06-3

A peptide, non-selective melanocortin receptor agonist for treatment for female sexual dysfunction; selectively stimulates solicitational behaviors in the female rat, without affecting lordosis, pacing, or other sexual behaviors, does not cause generalized motor activation; a peptide analogue of α-MSH.
H3268

PF-592379

 		710655-15-5

A potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM; displays >470 and 180-fold functional selectivity over D2 and D4 dopamine receptors, respectively; demonstrates activity in animal models of male erectile dysfunction.

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