Welcome to Hmobio!Global leader in active molecules.
Find Your Distributors

Select Your Country or Region

 $ USD

For research purposes only. Not for human experiments
You are here:Home-Inhibitors & Agonists-Antibiotics and Antivirals-Fungal

Request The Product List ofFungal Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes:

1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside.

2.  Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function.

3.   Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step.

4.  Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name CAS No. Information
H9225

Pyrimethanil

 		53112-28-0

Pyrimethanil is an effective broad-spectrum fungicide often used for the prevention of Botrytis cinerea. Pyrimethanil inhibits methionine biosynthesis and other amino acids, thereby affecting protein formation and cell division.
H9118

Thalifoline

 		21796-15-6

Thalifoline is an alkaloid isolated from the New Caledonian plant Cryptocarya longifolia and displays antifungal activity.
H8983

Amcipatricin

 		143483-67-4

Amcipatricin is a potent cell membrane permeability enhancers.
H8942

Fosciclopirox

 		1380539-06-9

Fosciclopirox a novel Mitosis inhibitors, treatment of urothelial cancers, in rats and dogs,is a Ciclopirox prodrug.
H1233

VT-1598

 		2089320-99-8

VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM; is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4; exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens.
H1232

VT-1161

 		1340593-59-0

VT-1161 is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM; demonstrates >2,000-fold selectivit over human CYP51, weakly inhibits human CYP2C9, CYP2C19, and CYP3A4; exhibits excellent potency against key yeast and dermatophyte strains.
H1231

Voriconazole

 		137234-62-9

Voriconazole is a a triazole antifungal agent that acts as a 14α-demethylase inhibitor; used to treat and prevent invasive fungal infections including aspergillosis andcandidiasis and fungal infections caused by Scedosporium and Fusarium species.

H1230

Terbinafine hydrochloride

 		78628-80-5

Terbinafine hydrochloride is a synthetic antifungal agent that inhibits the synthesis of ergosterol by inhibiting squalene epoxidase; used to treat ringworm, pityriasis versicolor, and fungal nail infections.
H1229

Terbinafine

 		91161-71-6

Terbinafine is a synthetic antifungal agent that inhibits the synthesis of ergosterol by inhibiting squalene epoxidase; used to treat ringworm, pityriasis versicolor, and fungal nail infections.
H1228

SCY-078

 		1207753-03-4

SCY-078 is a novel orally bioavailable fungal beta-1,3-D glucan synthetase inhibitor against Candida species C. glabrata (MIC 0.03 to 0.25 ug/ml), C. parapsilosis (MIC 0.06 to 0.25 ug/ml); shows actvity in an in vivo neutropenic murine model.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
© Copyright 2020 HmoBio. All Rights Reserved. Products are only for research use
沪ICP备2020027822号-1