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You are here:Home-Inhibitors & Agonists-GPCR-GPR39

Request The Product List ofGPR39 GPR39

Cat. No. Product Name CAS No. Information
H3373

TC G-1008

 		1621175-65-2

TC G-1008 is a potent, selective,orally bioavailable GPR39 agonist with EC50 of 0.4 and 0.8 nM for rat and human GPR39, respectively; displays high selectivity over a broad panel of kinases (IC50> 10 uM), and ghrelin and neurotensin-1 receptors (IC50>30 uM); robustly induces acute GLP-1 levels and shows the potential oral treatment of type 2 diabetes.
H3372

GPR39 agonist 7

 		1582736-32-0

GPR39 agonist 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels; activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling; a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.

H3371

GPR39 agonist 3

 		1582736-28-4

GPR39 agonist 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels; activates the orphan receptor GPR39, which signals to the Gli transcription factors and blocks signaling; a useful chemical tool for in vitro interrogation of GPR39 signaling in different cellular contexts.

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