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HIV (Human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells.


HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including apoptosis of uninfected bystander cells, direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.



References:


1.Zelalem Temesgen, et al. Ann Allergy Asthma Immunol 1999;83:1–7.

Cat. No. Product Name CAS No. Information
H9589

NBD-14270

 		2411819-82-2

NBD-14270 is a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses; NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM).
H9583

Pirmitegravir

 		2245231-10-9

Pirmitegravir is a potent and first-in-class inhibitor of allosteric integrase (ALLINI) that targets LEDGF/p75 binding site. Pirmitegravir displays picomolar IC50 in human PBMCs with a >24,000 therapeutic index against HIV-1. Pirmitegravir harbors outstanding anti-virus and safety properties.
H9561

Fipravirimat

 		1818867-24-1

Fipravirimat is a potent HIV-1 inhibitor. Fipravirimat has the potential for HIV and AIDS research.
H9545

Claficapavir

 		2055732-24-4

Claficapavir (A1752) is a specific nucleocapsid protein (NC) inhibitor with an IC50 around 1 μM; Claficapavir strongly binds the HIV-1 NC (Kd=20 nM) thereby inhibiting the chaperone properties of NC and leading to good antiviral activity against the HIV-1.
H9521

BMS-986224

 		2055200-88-7

BMS-986224 is a potent, selective and orally bioavailable APJ receptor agonist with Kd values of 0.3 nM; BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr1) apelin-13. BMS-986224 has the potential for the research of heart failure.
H9456

Elunonavir

 		2242428-57-3

Elunonavir is a highly potent HIV-1 protease inhibitor .
H9400

Clathrin-IN-1

 		1332879-52-3

Clathrin-IN-1 is a selective clathrin-mediated endocytosis (CME) inhibitor. Clathrin-IN-1 selectively inhibits amphiphysin association of clathrin terminal domain (TD) with an IC50 value of 12 μM. Clathrin-IN-1 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling.
H9386

BI-3257

 		1329989-31-2

BI-3257 is an inhibitor of HIV replication with nanomolar activity,BI-3257 displays an EC50 of 70 nM in a viral replication assay and induces disassembly of viral capsid structures with an IC50 of 160 nM. No cytotoxicity was found up to a concentration of 28 µM;It prevents the formation of the capsid core structure that encapsulates the viral genome and its associated enzymes, reverse transcriptase and integrase. BI-3257 binds to an induced pocket in the N-terminal domain of the capsid protein and induces significant structural changes (displacement of the α1-helix), likely affecting the protein-protein interactions that define the regular structures of the viral capsid core. The binding location of BI-3257-type compounds in the capsid monomer was elucidated by X-ray crystallography, and electron microscopy allowed the elucidation of its mode of action.
H9332

Labuvirtide

 		2395796-76-4

Labuvirtide is a potent HIV-1 inhibitor.
H8889

Tenofovir amibufenamide

 		1571076-26-0

Tenofovir amibufenamide is a potent tenofovir prodrug , drugs for treating viral infectious diseases, esp. HIV infection, hepatitis B and diseases caused by hepatitis B virus.

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