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Request The Product List ofRSV RSV

RSV (Respiratory syncytial virus) is a virus that causes respiratory tract infections. RSV is a negative-sense, single-stranded RNA virus of the family Paramyxoviridae, which includes common respiratory viruses such as those causingmeasles and mumps. RSV is a member of the paramyxovirus subfamily Pneumovirinae.

 RSV is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood.

Cat. No. Product Name CAS No. Information
H1527

Ziresovir

 		1422500-60-4

Ziresovir (AK-0529, AK0529) is a novel RSV F-protein inhibitor for treatment of Hospitalized Respiratory Syncytial Virus (RSV) fnfection.
H1526

YM-53403

 		851331-05-0

YM-53403 (YM53403)?is a specific anti-respiratory syncytial virus (RSV) agent with EC50 of 0.2 uM in plaque reduction assays; displays 100-fold more potent than ribavirin, an attractive compound for the treatment of RSV infection.
H1525

VP-14637

 		235106-62-4

VP-14637 (MDT-637) is a novel RSV fusion inhibitor with EC50 of 1.4 nM, reduces RSV replication by inhibition of the F-protein function; does not block RSV adsorption but inhibits RSV-induced cell-cell fusion and binds specifically to RSV-infected cells, specifically interacts with the RSV fusion protein expressed by a T7 vaccinia virus system; the F proteins containing the resistance mutations exhibits greatly reduced binding of VP-14637.
H1524

TMC353121

 		857066-90-1

TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC50 of 9.9, shows activity against groups A and B RSV and against a panel of clinical isolates with equal potency (EC50

H1523

RV521

 		1903763-82-5

Sisunatovir is a potent, orally active, small-molecule inhibitor of RSV fusion, demonstrates potent antiviral activity across multiple strains of RSV in vitro.
H1522

RSV604 racemate

 		676128-62-4

RSV604 racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer (RSV604).
H1521

RSV604 R enantiomer

 		932108-20-8

RSV604 R enantiomer is the R-enantiomer of RSV604, which is a potent respiratory syncytial virus (RSV) inhibitor targeting the nucleocapsid protein, is less active against RSV.
H1520

RSV604

 		676128-63-5

RSV604 (RSV-604) is a potent respiratory syncytial virus (RSV) inhibitor with EC50 of 0.86 uM in XTT assay, targets the nucleocapsid protein and is active post-RSV infection; RSV604 is also equipotent against 40 clinical isolates of RSV with an average EC50 of 0.8 μM by plaque reduction assay; The mutations (N105D, I129L, L139I, and I129L with L139I) within the nucleocapsid protein confer 5->20-fold reduced potentcy for RSV604; inhibits virus replication after mucosal inoculation in human airway epithelial cell model (EC50=0.5-0.9 uM).
H1519

RSV inhibitor compound 1

 		1422496-79-4

RSV inhibitor compound 1 is a novel potent, orally bioavailable RSV fusion inhibitor with EC50 of 2 nM (RSV Long strain infected HEp-2 cells) without significant cytotoxicity (CC50>100 uM); demonstrats single-digit nM anti-RSV activity against different RSV strains (RSV A2, RSV B with EC50 of 4 and 2 nM); also displays 1 log viral reduction in a female BALB/c mice RSV model by b.i.d. oral dosing at 12.5 mg/kg.
H1518

Presatovir

 		1353625-73-6

Presatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor with mean EC50 of 0.43 nM against a panel of 75 RSV A and B clinical isolates; exhibits low cytotoxicity in human cell lines and primary cell cultures (selectivity > 23,000-fold); shows excellent antiviral efficacy in the cotton rat model of RSV infection.

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