NF-κB inducing Kinase (NIK)|Inhibitors Agonists Modulators Antagonists|HmoBio.com

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Cat. No.	Product Name	CAS No.	Information
H5632	AM-0561	1202764-63-3	AM-0561 (AM0561) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 0.3 nM.
H5631	AM-0216	1202764-61-1	AM-0216 (AM0216) is a highly potent inhibitor of NF-κB inducing Kinase (NIK), example 294 in patent WO 2009158011 A1.
H5634	NIK SMI1	1660114-31-7	NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice.
H5633	Amgen16	1202761-92-9	Amgen 16 (Amgen16) is a highly potent inhibitor of NF-κB inducing Kinase (NIK) with Ki of 2 nM, selectively decrease viability of MMCLs in which NFkB activity is NIK-dependent; IKKβ inhibitor MLX and dexamethasone enhances cytotoxicity of NIK-inhibitors in MMCLs with NIK-dependent NFkB activation, blocks BAFF induced NFkB activation in myeloma cells combined with IKKβ inhibitors.