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Request The Product List ofCMV CMV

Cytomegalovirus (CMV) is a viral genus of the viral family known as Herpesviridae or herpesviruses. Within Herpesviridae, CMV belongs to the Betaherpesvirinae subfamily, which also includes the genera Muromegalovirus and Roseolovirus (HHV-6 and HHV-7). All herpesviruses share a characteristic ability to remain latent within the body over long periods. Although they may be found throughout the body, CMV infections are frequently associated with the salivary glands in humans and other mammals. Several species of Cytomegalovirus have been identified and classified for different mammals. Such as Human cytomegalovirus (HCMV), Chimpanzee cytomegalovirus (CCMV), Simian cytomegalovirus (SCCMV) and Rhesus cytomegalovirus(RhCMV) etc..


References


1.Griffiths P,et al. J Pathol. 2015 Jan;235(2):288-97.

Cat. No. Product Name CAS No. Information
H1174

Tomeglovir

 		233254-24-5

Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication; selectively inhibits not only HCMV strains, including ganciclovir-resistant clinical isolates, but also a number of monkey and rodent cytomegaloviruses.
H1173

GW 275175X

 		217950-62-4

GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation; shows antiviral efficacy against AD169 laboratory strain in DNA hybridization assays with IC50 of 0.7 uM, against 10 clinically relevant HCMV isolates with IC50 of 0.16-2.21 uM, and little or no activity against HSV-1, HSV-2 and varicella zoster virus; inhibits viral DNA maturation in a dose-dependent fashion.
H1172

Cidofovir dihydrate

 		149394-66-1

The prodrug of cidofovir diphosphate that inhibits cytomegalovirus (CMV) viral replication by selectively inhibiting viral DNA polymerases; also incorporates itself into viral DNA hence inhibiting viral DNA synthesis during reproduction.
H1171

Cidofovir

 		113852-37-2

The prodrug of cidofovir diphosphate that inhibits cytomegalovirus (CMV) viral replication by selectively inhibiting viral DNA polymerases; also incorporates itself into viral DNA hence inhibiting viral DNA synthesis during reproduction.
H1170

CFI02

 		273735-28-7

CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169; reduces HCMV yield by >3 logs at 1 uM, and shows no inhibitory activity against closely related betaherpesviruses (including MCMV, simian CMV, and RCMV) (IC50>20 uM) as well as cytotoxic effect (CC50>50 uM).
H1169

Brincidofovir

 		444805-28-1

Brincidofovir (CMX 001;Cidofovir HDP) is a lipid conjugate of the acyclic nucleotide phosphonate, cidofovir that shows activity against all five families of dsDNA viruses that cause human morbidity and mortality, including orthopoxviruses such as variola virus, the cause of human smallpox; has a number of advantages for treatment of smallpox in an emergency including greater potency in vitro against all dsDNA viruses that cause human disease, a high genetic barrier to resistance, convenient oral administration as a tablet or liquid, and no evidence to date of nephrotoxicity in either animals or humans.

H1168

BDCRB

 		142356-43-2

BDCRB (GW 275175) is a potent and selective inhibitor of human CMV replication by blocking the processing and maturation of viral DNA.

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