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You are here:Home-Inhibitors & Agonists-GPCR-Angiotensin Receptor

Request The Product List ofAngiotensin Receptor Angiotensin Receptor

Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Cat. No. Product Name CAS No. Information
H9532

Azilsartan mopivabil

 		2271428-31-8

Azilsartan mopivabil is the potent antagonist of angiotensin II receptor.
H9531

Azilsartan mepixetil

 		1596357-16-2

Azilsartan mepixetil is the antagonist of angiotensin II receptor; Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions.

H9127

AT2 receptor agonist C-21

 		477775-14-7

C-21 is a first specific non-​peptide AT2 receptor agonistt, on cardiac injury in rats with isoproterenol-​induced heart failure in vivo, with Ki values of 0.4 nM and >10 µM for the AT2 receptor and AT1 receptor, respectively.
H3035

Valsartan

 		137862-53-4

An angiotensin II receptor antagonist for treatment of high blood pressure and heart failure.
H3034

TD-0212

 		1073549-10-6

TD-0212 (TD0212) is a potent, orally efficacious, dual AT1 antagonist/Neprilysin (NEP) inhibitor with pKi of 8.9 (AT1) and pIC50 of 9.2 (NEP); produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and -independent hypertension, does not increase TPE at antihypertensive doses in rat tracheal plasma extravasation (TPE) models.
H3033

PD 123319 ditrifluoroacetate

 		136676-91-0

A potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.
H3032

PD 123319

 		130663-39-7

A potent, selective, non-peptide AT2 receptor with IC50 of 34 nM.

Heart Failure
H3031

Olmesartan medoxomil

 		144689-63-4

An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure.

H3030

Olmesartan

 		144689-24-7

An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure.

H3029

Losartan potassium

 		124750-99-8

A selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension).

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