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You are here:Home-Research Areas-Neurological Disease-Pain

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Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. It may come and go, or it may be constant. You may feel pain in one area of your body, such as your back, abdomen, chest, pelvis, or you may feel pain all over.

Pain can be helpful in diagnosing a problem. If you never felt pain, you might seriously hurt yourself without knowing it, or you might not realize you have a medical problem that needs treatment.

There are two types of pain: acute and chronic. Acute pain usually comes on suddenly, because of a disease, injury, or inflammation. It can often be diagnosed and treated. It usually goes away, though sometimes it can turn into chronic pain. Chronic pain lasts for a long time, and can cause severe problems.

Pain is not always curable, but there are many ways to treat it. Treatment depends on the cause and type of pain. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery.

Cat. No. Product Name CAS No. Information
H9405

(R)-Enflicoxib

 		251443-65-9

(R)-Enflicoxib is a novel,selective cyclo-oxygenase 2(COX-2) inhibitor.
H9404

(S)-Enflicoxib

 		251443-66-0

(S)-Enflicoxib is a novel cyclo-oxygenase 2 inhibitor.
H9399

AZD1940

 		881413-29-2

AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively. AZD1940 shows a robust analgesia action.
H9362

Zaloglanstat

 		1513852-12-4

Zaloglanstat is a non-opioid, potent, selective and orally bioavailable inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) currently in development for osteoarthritic pain.
H8935

Enflicoxib

 		251442-94-1

Enflicoxib is a potent cyclo-oxygenase 2 inhibitor with IC50  of  2.93 μM.
H8917

Vocacapsaicin

 		1931116-86-7

Vocacapsaicin is a first-in-class non-opioid therapeutic that rapidly converts to capsaicin, a potent TRPV1-agonist;CA-008 provides long-lasting pain relief after a single, local injection by selectively desensitizing pain-conducting nerve fibers, without producing numbness or weakness.
H8768

Otenaproxesul

 		1000700-29-7

Otenaproxesul an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2) ATB-346 possesses antiinflammatory and antinociceptive activities
H8078

PF-06273340

 		1402438-74-7

PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively; displays selectivity over a panel of ion channels, receptors and other enzymes; exhibits in vivo efficacy in a rodent model of inflammatory pain.
H8054

ALE-0540

 		234779-34-1

ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively; produces antiallodynic actions in models of neuropathic pain.
H6292

Difluprednate

 		23674-86-4

A FDA approved topical corticosteroid indicated for the treatment of inflammation and pain associated with ocular surgery.

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