| Cat. No. |
Product Name |
CAS No. |
Information |
| H9304 |
SMIP 004
|
143360-00-3 |
SMIP 004 is a potent SKP2 (S-phase kinase-associated protein 2) inhibitor. Upregulates p27 and activates the unfolded protein response (UPR) in LNCaP prostate cancer cells overexpressing SKP2; Also induces oxidative stress. Induces proteasomal degradation of cyclin D1 and acts as CDK2 inhibitor. Arrests cell cycle in G1 phase and induces apoptosis in prostate cancer cells, but not normal cells in vitro. Inhibits growth of breast and prostate cancer xenografts in mice. Also induces autophagy and reduces replication of MERS-CoV in VeroB4 cells. |
| H7180 |
Tasisulam
|
519055-62-0 |
Tasisulam (LY 573636) is a small molecule antitumor agent that induces apoptosis via the intrinsic pathway, resulting in cytochrome c release and caspase-dependent cell death; shows antiproliferative effect against a variety of human hematopoietic malignancies, including AML, B-ALL, large B-cell and mantle cell lymphoma cell lines; promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation; causes aberrant pre-mRNA splicing.
|
| H7179 |
TAME hydrochloride
|
1784-03-8 |
TAME is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1); inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 uM; promotes Cdc20 autoubiquitination, blocks cyclin degradation in interphase extract. |
| H7178 |
TAME
|
901-47-3 |
A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1); inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 uM; promotes Cdc20 autoubiquitination, blocks cyclin degradation in interphase extract. |
| H7177 |
SZL P1-41
|
222716-34-9 |
A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro; specific diminishes E3-ligase activity of Skp2-SCF complex, but not of other F-box SCF complex; inhibits Skp2-mediated p27 ubiquitination, induced endogenous p27 protein expression in prostate cancer cells; exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. |
| H7176 |
Suramin sodium salt
|
129-46-4 |
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces accumulation of CRL substrates; also inhibits multiple viruses (ZIKVs, EV71).
|
| H7175 |
SPOP-IN-6b
|
2136270-20-5 |
SPOP-IN-6b is a potent, small-molecule E3 Ligase adaptor SPOP (speckle-type POZ protein) inhibitor that inhibits the SPOP-substrate protein interaction with IC50 of 35 uM (inhibits puc-SBC1 peptide binding to SPOP); suppresses oncogenic SPOP-signaling pathways, and kills human ccRCC cells that are dependent on oncogenic cytoplasmic SPOP. |
| H7174 |
Skp2-IN-C1
|
432001-69-9 |
Skp2-IN-C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, induced p27 accumulation in a Skp2-dependent manner and promoted cell-type-specific blocks in the G1 or G2/M phases. |
| H7173 |
SCF-I2
|
99827-46-0 |
An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas; does not affect the activity of the closely related E3 enzyme SCFMet30, inhibits binding and/or ubiquitination of both full length Sic1 and Far1 with IC50 of 60 uM. |
| H7172 |
PRT-4165
|
31083-55-3 |
PRT-4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation; inhibits the E3 ubiquitin ligase activity of PRC1, but not RNF8; inhibits double-strand breaks (DSBs) repair. |
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