Welcome to Hmobio!Global leader in active molecules.
Find Your Distributors

Select Your Country or Region

 $ USD

For research purposes only. Not for human experiments
You are here:Home-Antibody Drug Conjugates-ADCs Linker/Click Chemistry

Request The Product List ofADCs Linker/Click Chemistry ADCs Linker/Click Chemistry

Antibody-drug conjugates (ADCs) consist of a desirable monoclonal antibody, an active cytotoxic drug and an appropriate linker. An appropriate linker between the antibody and the cytotoxic drug provides a specific bridge, and thus helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers maintain ADCs’ stability during the preparation and storage stages of the ADCs and during the systemic circulation period.

The ADCs currently undergoing clinical evaluation contain linkers are mostly classified into two categories: cleavable and noncleavable. Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell. Noncleavable linkers require proteolytic degradation of the antibody portion of the ADC for release of the cytotoxic molecule, which will retain the linker and the amino acid by which it was attached to the antibody.

The selection of linker is target dependent, based on the knowledge of the internalization and degradation of the antibody-target antigen complex, and a preclinical in vitroand in vivo activity comparison of conjugates. Moreover, the choice of a linker is also influenced by which cytotoxin is used, as each molecule has different chemical constraints, and frequently the drug structure lends itself to a specific linker.

Cat. No. Product Name CAS No. Information
H9114

Fmoc-Gly-Gly-D-Phe-OH

Fmoc-Gly-Gly-D-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Gly-Gly-D-Phe-OH is the D-isomer of Fmoc-Gly-Gly-Phe-OH.
H9113

Fmoc-Gly-Gly-Phe-OH

 		160036-44-2

Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
H8585

DBCO-PEG4-MMAF

 		2360411-65-8

DBCO-PEG4-MMAF is a drug-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4.
H8428

DBCO Maleimide

 		1395786-30-7

DBCO Maleimide is a Click Chemistry intermidate used for antibody-drug conjugates.
H8427

DBCO-Biotin

 		1418217-95-4

DBCO-Biotin is a Click Chemistry intermidate used for antibody-drug conjugates.
H8426

Fmoc-Val-Cit-PAB-PNP

 		863971-53-3

A cathepsin B-cleavable dipeptide linker for antibody-drug-conjugation (ADC).
H8425

DBCO acid 4

 		1618102-42-3

DBCO acid 4 is a Click Chemistry intermidate used for antibody-drug conjugates.
H8424

DBCO acid 5

 		1337920-25-8

DBCO acid 5 is a Click Chemistry intermidate used for antibody-drug conjugates.
H8423

DOTA-ADIBO

 		1374865-01-6

DOTA-ADIBO is a Click Chemistry intermidate used for antibody-drug conjugates.
H8422

DBCO-PEG4 amine

 		1255942-08-5

DBCO-PEG4 amine (ADIBO-PEG4-amine) is a Click Chemistry intermidate used for antibody-drug conjugates.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
© Copyright 2020 HmoBio. All Rights Reserved. Products are only for research use
沪ICP备2020027822号-1