Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Cat. No. | Product Name | CAS No. | Information |
---|---|---|---|
H9279 |
SOR-C13 |
1187852-48-7 | SOR-C13, is a novel, short, synthetic peptide,potent TRPV6 Calcium Channel Inhibitor. |
H9230 |
SNX-482 |
203460-30-4 | SNX-482, a peptidyl toxin of the spider Hysterocrates gigas, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM; SNX-482 has antinociceptive effec. |
H9229 |
ProTx-I |
484598-35-8 | ProTx-I is a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively; ProTx-I is also a potent blocker for voltage-gated Na+ channels and inhibits KV 2.1 channels. |
H9228 |
SR33805 |
121345-64-0 | SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively; SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts. |
H9227 |
CALP2 TFA |
CALP2 TFA is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site; CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages. |
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H9226 |
CALP2 |
261969-04-4 | CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site; CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages. |
H9117 |
sFTX-3.3 |
141997-14-0 | sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels. |
H9092 |
VK-II-86 |
955371-84-3 | VK-II-86 is a novel selective ryanodine receptor type 2 (RyR2) antagonists. |
H6428 |
Ionomycin calcium salt |
56092-82-1 | Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus, used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes; also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. |
H6427 |
Ionomycin |
56092-81-0 | Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus; used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes; also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. |
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