Cat. No. | Product Name | CAS No. | Information |
---|---|---|---|
H5759 |
FOXO1-IN-8 |
A small molecule, selective FOXO1 inhibitor that inhibits FOXO-dependent glucose production devoid of lipogenic activity in hepatocytes; shows beneficial effects of FOXO1 inhibition on diabetic hyperglycemia by reducing hepatic glucose production. |
|
H5758 |
AS-1842856 |
836620-48-5 | A novel transcription factor Foxo1 inhibitor that potently and selectively inhibits Foxo1-mediated transactivation with IC50 of 33 nM, with no significant activity on Foxo3a and Foxo4; reduces glucose production through the inhibition of G6pase and phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels in a rat hepatic cell line; decreases fasting plasma glucose level in diabetic db/db mice. |
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