| Cat. No. |
Product Name |
CAS No. |
Information |
| H2125 |
TH-257
|
2244678-29-1 |
TH-257 (TH257) is a potent, selective, allosteric inhibitor of LIMK1 and LIMK2 with IC50 of 84 nM for LIMK1 and 39 nM for LIMK2 in a RapidFire MS assay; TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 uM; displays IC50 of 250 nM against ectopically expressed full-length LIMK1 and 150 nM LIMK2 in a life cell NanoBRET assay. |
| H2124 |
T56-LIMKi
|
924473-59-6 |
A novel specific LIMK2 inhibitor; reduces phosphorylated cofilin (p-cofilin) by LIMK2 but not by LIMK1 and inhibits (IC50=30 uM) the proliferation in NF1−/− MEFs; synergizes with salirasib to destabilize the actin cytoskeleton, decreases anchorage-independent cell growth of NF1−/− MEFs; reduces tumor size and p-cofilin levels in a nude mouse Panc-1 xenograft model. |
| H2123 |
SR7826
|
1219728-20-7 |
SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM, displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold); inhibits only Limk1 and STK16 with >80% inhibition at 1 uM in a panel of 61 kinases; potently inhibits cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50
|
| H2122 |
R-10015
|
2097938-51-5 |
A potent, selective inhibitor of human LIMK1 with IC50 of 38 nM ; exhibits good selectivity, with off-target inhibition of only LRRK2 and p70S6K (≥90% inhibition at 1 uM) and moderate inhibition of PKA (76%), ROCK2 (70%), and FLT3 (68%); blocks HIV-1 viral DNA synthesis, nuclear migration, and virion release; has broad-spectrum antiviral effect and inhibits multiple viruses, including EBOV, RVFV, VEEV, and HSV-1. |
| H2121 |
Pyr-1
|
83947-94-8 |
A novel potent, selective, cell permeable and ATP competitive LIMK inhibitor; stabilizes microtubules, induces a cell-cycle arrest at the S-G2–M phases, and blocks actin microfilament dynamics through inhibition of cofilin phosphorylation; blocks the invasion and proliferation of breast cancer cells, including paclitaxel-resistant cells, in vitro and tumor growth and metastasis in vivo in tumor xenograft. |
| H2120 |
LX7101
|
1192189-69-7 |
LX7101 is a potent, dual LIMK and ROCK inhibitor with IC50 of 4.3/32//69/32/ nM for LIMK2/LIMK1/ROCK1/ROCK2, respectively; kinase selectivity are eveluated in a panel of binding assays including 78 different receptors and transporters at Cerep (only 5 have >60% inhibition at 10 uM); demonstrates high efficacy in mouse model of ocular hypertension, ans shows potential for the treatment of glaucoma. |
| H2119 |
LIMK1 and 2 dual inhibitor
|
2215049-71-9 |
LIMK1 and 2 dual inhibitor is a potent, selective LIMK1/2 inhibitor with IC50 of <10 nM for both, 15-fold selectivity over B-Raf (IC50=10-100 nM); inhibits p-c-ofilin at Ser3 site, suppresses cell proliferation of MV-411 cell of with IC50 of 1-5 uM. |
| H2118 |
LIMK-IN-22j
|
1116571-01-7 |
A potent, selective LIMK inhibitor with IC50 of 3.2 nM and 1.2 nM for LIMK1 and LIMK2, respectively; displays >100-fold selectivity for LIMK2 against ROCK1 and >900-fold selectivity against ROCK2; reduces intraocular pressure to baseline levels in a steroid induced mouse model of ocular hypertension (topical dosing). |
| H2117 |
LIMK-IN-14
|
1116570-97-8 |
A potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively; displays >100-fold selectivity for LIMK2 against ROCK1 and >900-fold selectivity against ROCK2; reduces intraocular pressure to baseline levels in a steroid induced mouse model of ocular hypertension (topical dosing). |
| H2116 |
CRT-0105950
|
1661845-86-8 |
A novel potent LIMK inhibitor with IC50 of 0.3 nM and 1 nM for LIMK1 and LIMK2, respectively; inhibits cofilin phosphorylation and increase αTubulin acetylation in cells; shows significant sensitivity against 656 cancer cell lines, and rhabdomyosarcoma, neuroblastoma and kidney cancer cells (mean EC50=19.2 uM). |
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