| Cat. No. |
Product Name |
CAS No. |
Information |
| H9601 |
MC2652
|
1228143-79-0 |
MC2652 is a potent LSD1 inhibitor. MC2652 displays high inhibiting effects in MV4-11 and NB4 leukaemia cells. MC2652 shows antiproliferative activity against prostate cancer LNCaP cells. |
| H9409 |
TAK-418
|
1818252-53-7 |
TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM; TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models. |
| H9067 |
CC-90011
|
2097523-60-7 |
CC-90011 (Pulrodemstat tosylate)is a potent and selective reversible inhibitor of lysine specific demethylase 1 (LSD1) with IC50 value of 0.3 nM;And induction of on-target cellular differentiation marker CD11b in THP-1 cell line with EC50 = 7 nM, antiproliferative activity in AML kasumi-1 cells with EC50 = 2 nM, and no effect in normal human fibroblasts (IMR-90). |
| H9066 |
CC-90011 free base
|
1821307-10-1 |
CC-90011 free base is a potent and selective reversible inhibitor of lysine specific demethylase 1 (LSD1) with IC50 value of 0.3 nM;And induction of on-target cellular differentiation marker CD11b in THP-1 cell line with EC50 = 7 nM, antiproliferative activity in AML kasumi-1 cells with EC50 = 2 nM, and no effect in normal human fibroblasts (IMR-90). |
| H8932 |
Bomedemstat
|
1990504-34-1 |
Bomedemstat(IMG 7289) is a potent,orally administered Lysine Specific Demethylase 1(LSD1) inhibitor. |
| H2701 |
Vafidemstat
|
1357362-02-7 |
Vafidemstat is a novel potent, selective lysine-specific histone demethylase (LSD1) inhibitor. |
| H2700 |
T-448 free base
|
1597426-52-2 |
T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts; increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction, shows unique therapeutic approaches for central nervous system disorders associated with epigenetic dysregulation. |
| H2699 |
T-448
|
1597426-53-3 |
T-448 (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts; increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction, shows unique therapeutic approaches for central nervous system disorders associated with epigenetic dysregulation. |
| H2698 |
T-3775440 hydrochloride
|
1422535-52-1 |
A novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models. |
| H2697 |
T-3775440
|
1422620-34-5 |
T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models. |
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