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Request The Product List ofTNF-alpha TNF-alpha

    TNF-alpha(TNF-α) is a 17-kDa protein consisting of 157 amino acids that is a homotrimer in solution. In humans, the gene is mapped to chromosome 6. Its bioactivity is mainly regulated by soluble TNF-α–binding receptors. TNF-α is mainly produced by activated macrophages, T lymphocytes, and natural killer cells. Lower expression is known for a variety of other cells, including fibroblasts, smooth muscle cells, and tumor cells. In cells, TNF-α is synthesized as pro-TNF (26 kDa), which is membrane-bound and is released upon cleavage of its pro domain by TNF-converting enzyme (TACE).

Cat. No. Product Name CAS No. Information
H1754

UTL-5g

 		646530-37-2

UTL-5g (GBL-5g) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity; lowers elevated levels of AST, ALT, creatinine, BUN, and TNF-α, increases the reduced platelet count in mice; a novel chemo- and radioprotective agent.
H1753

TNFα-IN-C87

 		332420-90-3

A novel and highly specific small-molecule TNFα inhibitor that directly binds to TNFα, potently inhibits TNFα-induced cell death (IC50=8.73 uM) and effectively blocks TNFα-triggered signaling activities; effectively attenuates TNFα-induced inflammation in a murine acute hepatitis model.
H1752

SPD-304

 		869998-49-2

SPD-304 is an inhibitor of tumor necrosis factor α (TNFα) that prevents binding to the TNF Receptor 1 (TNFR1) with IC50 of 22 uM; binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine; inhibits TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 uM in a cell based assay.
H1751

Pomalidomide

 		19171-19-8

A potent inhibitor of TNF-α production; inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs; upregulates interferon gamma, IL-2 and IL-10.
H1750

Mitochonic Acid 35

 		1611470-23-5

A dual inhibitor of TNF-α and TGF-β1 by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation; attenuates the LPS/GaIN-induced hepatic inflammation in the mice, and downregulates TGF-β1-induced fibrotic gene expression; attenuates renal inflammation and fibrosis with the downregulation of inflammatory cytokines and fibrotic gene expressions in renal fibrosis model.
H1749

LMP-420

 		473870-63-2

A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells; also shows potent cytotoxic effects for CLL cells (ED50=245 nM, 72h) and minimal toxicity for normal hematopoietic cells; decreases colonic TNF levels in IL-10-deficient mice with chronic colitis.
H1748

JNJ525

 		2092913-64-7

JNJ525 is a small molecule inhibitor of TNFα that prevents the formation of TNFα complexes with TNFR1 and TNFR2 with IC50 of 1.2 uM and 1.1 uM in the TR-FRET assay, respectively.
H1747

IW-927

 		389142-48-7

A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM); also blocks TNF-stimulated phosphorylation of Ikappa-B in Ramos cells (IC50=600 nM)

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