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You are here:Home-Inhibitors & Agonists-Proteasome/Ubiquitin-Heat Shock Protein (HSP)

Request The Product List ofHeat Shock Protein (HSP) Heat Shock Protein (HSP)

HSP (Heat shock proteins) are a group of proteins induced by heat shock, the most prominent members of this group are a class of functionally related proteins involved in the folding and unfolding of other proteins. HSP expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins appear to serve a significant cardiovascular role. Hsp90, Hsp84, Hsp70, Hsp27, Hsp20 and alpha B crystallin all have been reported as having roles in the cardiovasculature.

Cat. No. Product Name CAS No. Information
H9607

NPX-800

 		1693734-80-3

NPX-800 is a potent, selective, oral heat shock factor 1 (HSF1) pathway inhibitor.
H9543

Cemdomespib

 		1450642-92-8

Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response.
H9059

Compound DTHIB

 		897326-30-6

Compound DTHIB is a potent direct targeted HSF1 inhibitor,EC50 for DTHIB in C4-2 cells with 0.98 μM ,DTHIB exhibited suppressing growth of various cancer cells.
H8921

Zelavespib

 		873436-91-0

PU-H71 is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells.
H8846

Icapamespib

 		1000999-96-1

Icapamespib is a novel Heat-​shock protein 90 (HSP90) inhibitor.
H7246

YZ129

 		1643120-60-8

YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM; also suppressed the expression of NFAT-regulated genes, such as COX2, MMP7, and MMP9, in U87 GBM cells; directly binds to HSP90 to antagonize its chaperoning effect on calcineurin, a Ca2+-sensitive phosphatase that is required for NFAT nuclear translocation and subsequent gene expression; YZ129 could not only suppress cancer cell growth but also reduce cancer cell movement and migration of of GBM cells in vitro; suppresses the growth of GBM xenografts in vivo.
H7245

YM-1

 		409086-68-6

YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM; enhances client protein ubiquitination and polyQ AR degradation; alleviates toxicity in a Drosophila model of spinobulbar muscular atrophy (SBMA); also disrupts the Hsp70-Bag3 interaction with IC50 of 5 uM.
H7244

YK5

 		1268273-23-9

YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells.
H7243

VER-155008

 		1134156-31-2

A potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78; shows cellular activity in HCT116 cells (GI50= 5uM), has similar potencies in both Grp78 and Hsp70; inhibits the proliferation of human breast and colon cancer cell lines with GI50s of 5.3-14.4 uM, and induces Hsp90 client protein degradation in both HCT116 and BT474 cells; induced caspase-3/7 dependent apoptosis in BT474 cells.
H7242

TRC-051384

 		867164-40-7

A potent heat shock protein 70 (HSP70) inducer, involves HSF1 activation; significantly reduces stroke associated neuronal injury and disability in a rat model of transient ischemic stroke; delays thrombus formation without increased bleeding risk in mice.

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