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You are here:Home-Inhibitors & Agonists-Others-Human Antigen R (HuR)

Request The Product List ofHuman Antigen R (HuR) Human Antigen R (HuR)

Cat. No. Product Name CAS No. Information
H6089

Okicenone

 		137018-54-3

A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 90 nM; interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation, and is a valuable tool for studying HuR function;
H6088

MS-444

 		150045-18-4

A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM; interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation, and is a valuable tool for studying HuR function; augmentes DSS-induced weight loss and increases tumor multiplicity, size, and invasiveness in mice model of inflammatory colon cancer, also abrogates tumor cell apoptosis and depletes tumor-associated eosinophils, accompanied by a decrease in IL18 and eotaxin-1.
H6087

HuR inhibitor 5

 		328254-90-6

A newly identified, small molecule HuR inhibitor that disrupts HuR multimerization modules and reduces tumor cell survival and proliferation.
H6086

Dihydrotanshinone I

 		87205-99-0

A natural product that prevents HuR/RNA complex formation with Ki of 3.74 nM; influences mRNA stability and translational efficiency of TNF in a HuR-dependent manner and also other functional readouts of its post-transcriptional control, such as the stability of selected pre-mRNAs in breast cancer cell lines; disrupts HuR multimerization modules and reduces tumor cell survival and proliferation, potently inhibits xenograft tumor growth in a HuR-dependent model without systemic toxicity in vivo.
H6085

Dehydromutactin

 		823803-77-6

Dehydromutactin is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 40 nM; interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation, and is a valuable tool for studying HuR function.
H6084

CMLD-2

 		958843-91-9

A novel small molecule disruptor of HuR-mRNA interaction with Ki of 350 nM; causes G1 phase cell-cycle arrest and induces apoptosis in NSCLC cells, decreases HuR mRNA and the mRNAs of HuR-regulated proteins (Bcl2 and p27); displays cytotoxic selectivity on cancer cells and blocks HuR protein bound to Msi1 and XIAP mRNAs, thereby decreasing target mRNA stability and protein levels as well as inhibiting the Wnt signaling pathway.
H6083

Azaphilone-9

 		1448460-87-4

A fungal natural product that binds to HuR and inhibits HuR-RNA interaction in vitro with IC50 of 1.2 uM; inhibits HuR-AU-rich elements (ARE) interaction and blocks key RNA-binding residues of HuR.

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