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You are here:Home-Inhibitors & Agonists-Cytoskeleton/Cell Adhesion Molecules-Microtubule/Tubulin

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Microtubules are a component of the cytoskeleton, found throughout the cytoplasm. These tubular polymers of tubulin can grow as long as 50 micrometres, with an average length of 25 µm, and are highly dynamic. The outer diameter of a microtubule is about 24 nm while the inner diameter is about 12 nm. Microtubules are found in eukaryotic cells and are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin. Tubulin is one of several members of a small family of globular proteins. The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family which is present only in kinetoplastid protozoa. The most common members of the tubulin family are α-tubulin and β-tubulin, the proteins that make up microtubules. Microtubules are very important in a number of cellular processes. They are involved in maintaining the structure of the cell.

Cat. No. Product Name CAS No. Information
H9125

BTB-1

 		86030-08-2

BTB-1 is a potent, selective and reversible mitotic motor protein KIF18A inhibitor with an IC50 of 1.69 μM.
H9124

KIF18A inhibitor compound 18

 		2446341-65-5

KIF18A inhibitor compound 18 is a novel KIF18A inhibitor with IC50 value of 0.012 μM,ues for Treating Cancer.
H9123

KIF18A inhibitor compound 1

 		2446341-84-8

KIF18A inhibitor compound 1 is a novel KIF18A inhibitor with IC50 value of 0.012 μM,ues for Treating Cancer.
H8548

CUN25391

 		105925-39-1

CUN25391, also known as Tubulin inhibitor 6 or iHAP1 is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. CUN25391 inhibits tubulin polymerization with an IC50 of 0.87 μM.
H2414

Vinorelbine ditartrate

 		125317-39-7

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.
H2413

Vinorelbine

 		71486-22-1

Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.
H2412

Vinblastine

 		865-21-4

A cytotoxic alkaloid that binds tubulin and inhibits the assembly of microtubules; a chemotherapy agent for treatment of a number of types of cancer.

Approved
H2411

VERU-111 analogue 13f

 		2250081-53-7

VERU-111 analogue 13f is a novel potent colchicine binding site inhibitor (CBSI) in tubulin with potential anticancer activities; inhibits cell viability of human melanoma cell lines (A375, M14, and RPMI7951) with IC50 of 1-3 nM; VERU-111 analogue 13f is significantly more potent than VERU-111, exhibits a strong inhibitory effect on tumor growth in vivo.
H2410

VERU-111

 		1332881-26-1

VERU-111 is an oral, first-in-class alpha and beta tubulin inhibitor ,inhibits cell viability of human melanoma cell lines (A375, M14, and RPMI7951) with IC50 of 5-10 nM;cytoskeleton disruptor small molecule for the treatment of metastatic castration resistant and androgen receptor targeting agent resistant prostate cancer.  
H2409

TR-100

 		1128165-86-5

TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments; perturbs Tpm3.1-regulated actin filament depolymerisation from the barbed end without affecting the capacity of Tpm3.1 to regulate barbed end actin elongation or bind F-actin; TR-100 (TR100) is effective in vitro and in vivo in reducing tumor cell growth in neuroblastoma and melanoma models.

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