| Cat. No. |
Product Name |
CAS No. |
Information |
| H9068 |
BJG-03-025
|
2553213-90-2 |
BJG-03-025 is a potent and highly selective focal adhesion kinase (FAK) inhibitor with IC50 value of 20 nM. |
| H8998 |
PND-1186
|
1061353-68-1 |
PND-1186(VS-4718)is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis. |
| H8997 |
PND-1186 hydrochloride
|
1356154-94-3 |
PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis. |
| H8647 |
PF-719
|
1404454-02-9 |
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
| H7928 |
Y15
|
4506-66-5 |
FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK; does not significantly decrease kinase activity of the other kinases (Pyk2 autophosphorylation); directly and specifically decreases Y397-phosphorylation of FAK in vitro, inhibits cancer cell viability in vitro, causes detachment, decreases cell adhesion and blocks tumor growth in vivo. |
| H7927 |
TAS-301
|
193620-69-8 |
An inhibitor of smooth muscle cell migration and proliferation; inhibits PDGF-induced tyrosine phosphorylation of both FAK and paxillin; also inhibits PDGF-induced elevation of [Ca2+]i and activation of CaMK II, reduces the extent of F-actin stress fiber depolymerization observed in response to PDGF at 10 uM. |
| H7926 |
Pyk2-IN-25a
|
2052970-45-1 |
Pyk2-IN-25a is a highly potent Pyk2 (PTK2B) inhibitor with IC50 of 0.67 nM, dispalys 2-fold weakening potency for FAK (IC50=1.26 nM); a suitable tool compound for future proof-of-concept studies. |
| H7925 |
PF-719 dihydrochloride
|
|
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM); does not have significant inhibitory effects on recombinant MLCK2, p38, Akt1, or ROCK1, and very little inhibtion at Src family kinases (IC50>5 uM); selectively inhibits tyrosine phosphorylation of Pyk2 at 1 uM, but blocks both Pyk2 and FAK phosphorylation at 2.5 uM in A20 cells; reduces chemoattractant-induced migration of B-2 and MZ B cells. |
| H7924 |
PF-573228
|
869288-64-2 |
A potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM; displays 250-fold selectivity over Pyk2, 50–250-fold over a panel of kinases (CDK1, CDK7, GSK3β); inhibits FAK phosphorylation on Tyr397 in cultured cells (IC50=30-100 nM), inhibits both chemotactic and haptotactic migration. |
| H7923 |
PF-562271 besylate
|
939791-38-5 |
A potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively; displayes robust inhibition in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM; inhibits FAK phosphorylation in vivo in a dose-dependent fashion (EC50=93 ng/mL) after in tumor-bearing mice; orally bioavailable. |
$ USD
Select Your Country or Region