E3 Ligase Ligand-Linker Conjugate|Inhibitors Agonists Modulators Antagonists|HmoBio.com

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Cat. No.	Product Name	CAS No.	Information
H8621	Pomalidomide 4'-alkylC5-acid	2225940-49-6	Pomalidomide 4'-alkylC5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.
H8454	E3 Ligand-Linker Conjugate 3	1799711-24-2	An E3 ligase ligand-linker conjugate for PROTAC.
H8453	E3 Ligand-Linker Conjugate 2	2098492-26-1	An E3 ligand- Linker Conjugate for PROTAC.
H8452	E3 Ligand-Linker Conjugate 4	2093388-45-3	An E3 ligase ligand-linker conjugate for PROTAC.
H8451	E3 Ligand-Linker Conjugate 1	2098488-36-7	E3 Ligand-Linker Conjugate 1 is an E3 ligand- Linker Conjugate for PROTAC.
H8450	E3 Ligand-Linker Conjugate 10	1957236-22-4	An E3 ligase ligand-linker conjugate for PROTAC.
H8449	E3 Ligand-Linker Conjugate 6	2022182-57-4	An E3 ligase ligand-linker conjugate for PROTAC.
H8448	E3 Ligand-Linker Conjugate 7	2022182-59-6	An E3 ligase ligand-linker conjugate for PROTAC.
H8447	E3 Ligand-Linker Conjugate 8	1957235-74-3	An E3 ligase ligand-linker conjugate for PROTAC.
H8446	E3 Ligand-Linker Conjugate 5	2093388-69-1	E3 Ligand-Linker Conjugate 5 is an E3 ligase ligand-linker conjugate for PROTAC.

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