| Cat. No. |
Product Name |
CAS No. |
Information |
| H9569 |
Izilendustat hydrochloride
|
1303513-80-5 |
Izilendustat hydrochloride is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2);Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases |
| H9568 |
Izilendustat
|
1303512-02-8 |
Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2);Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases |
| H9522 |
BPC 157
|
137525-51-0 |
BPC 157 is a stable gastric pentadecapeptide and a partial sequence of the human gastric juice protein BPC;BPC 157 is an anti-ulcer peptidergic agent with no reported toxicity. BPC 157 links inflammatory bowel disease and multiple sclerosis. |
| H8930 |
Belzutifan
|
1672668-24-4 |
PT2977 (MK-6482) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. PT2977, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. PT2977 is a potential treatment for clear cell renal cell carcinoma (ccRCC). |
| H5818 |
Vadadustat
|
1000025-07-9 |
Vadadustat (PG-1016548, AKB-6548)?is a novel, potent, orally active HIF-PH inhibitor in development for the treatment of anemia in both nondialysis-dependent (NDD) and dialysis-dependent CKD; induces endogenous erythropoietin synthesis and enhances iron mobilization. |
| H5817 |
TP-0463518
|
1558021-37-6 |
TP-0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively; demonstrates to promote the production of erythropoietin (EPO) following oral administration in mice and rats, shows potential for treatment of renal anemia. |
| H5816 |
THS-044
|
62054-67-5 |
THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM); modulates the affinity of the HIF2α:ARNT PAS-B heterodimer in vitro. |
| H5815 |
SYP-5
|
1384268-04-5 |
A novel potent HIF-1 inhibitor that inhibits hypoxia-induced upregulation of HIF-1, suppresses tumor cells invasion and angiogenesis; down-regulates VEGF and MMP-2, suppresses angiogenesis induced by hypoxia and VEGF in vitro; inhibits tumor cell migration and invasion by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. |
| H5814 |
Roxadustat
|
808118-40-3 |
Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM; FG-4592 stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, demonstrates potential for treatment of anemia. |
| H5813 |
PX-478
|
685898-44-6 |
A potent, selective inhibitor of HIF-1α and HIF-1 transcription factor activity; inhibits the hypoxia-induced increase in HIF-1α protein in PC-3, MCF-7, HT-29 and Panc-1 with IC50 of 3.9, 4.0, 19.4 and 10.1 nM, respectively; suppresses HIF-1α levels in HT-29 human colon cancer xenografts and inhibits the expression of HIF-1 target genes including VEGFR and the glucose transporter-1.
|
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