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You are here:Home-Inhibitors & Agonists-Antibiotics and Antivirals-HSV

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HSV (Herpes simplex virus) can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks. Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with ascab characteristic of herpetic disease.

As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks.

Cat. No. Product Name CAS No. Information
H9631

MEDS-433

 		2241027-61-0

MEDS-433 is a potent DHODH inhibitor with IC50 of 1.2 nM (hDHODH), inhibits in vitro replication of HSV-1 and HSV-2 in the nanomolar range;MEDS-433 targets the de novo pyrimidine biosynthesis.MEDS-433 exhibited highly synergistic antiviral activity when combined with acyclovir and dipyridamole.MEDS-433 is a promising candidate as either single agent or in combination regimens with existing direct-acting anti-HSV drugs.
H1428

Valacyclovir hydrochloride

 		124832-27-5

An antiviral agent that acts as a very potent inhibitor of viral DNA polymerase; a prodrug of aciclovir for management of herpes simplex (HSV), herpes zoster and herpes B infection.
H1427

Valacyclovir

 		124832-26-4

Valacyclovir is an antiviral agent that acts as a very potent inhibitor of viral DNA polymerase; a prodrug of aciclovir for management of herpes simplex (HSV), herpes zoster and herpes B infection.
H1426

Penciclovir

 		39809-25-1

A guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections; inhibits viral DNA polymerase and exhibits low toxicity and good selectivity.
H1425

FV-100

 		956483-03-7

FV-100 (Valnivudine, CF-1743) is a potent, selective, bicyclic nucleoside analogue inhibitor of varicella zoster virus (VZV) with EC50 of subnanomolar range in vitro.
H1424

Fiacitabine

 		69123-90-6

A synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent; suppresses various strains of HSV1 and HSV2 with IC90 of 2.5 nM and 12.6 nM, respectively, shows minimal cytotoxicity; more potent than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine.
H1423

Famciclovir

 		104227-87-4

A guanine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections.

H1422

Amenamevir

 		841301-32-4

A potent viral helicase-primase inhibitor that possesses antiviral activity against VZV, HSV1 and HSV2 with EC50 of 0.028-0.1 uM; exerts equipotent activity against VZV, HSV-1 and HSV-2 through prevention of viral DNA replication; also shows activity against aciclovir-resistant VZV.
H1421

Acyclovir

 		59277-89-3

An antiviral agent that competitively inhibits and inactivates HSV-specified DNA polymerases preventing further viral DNA synthesis without affecting the normal cellular processes; primarily used for the treatment of HSV infections.

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