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You are here:Home-Inhibitors & Agonists-GPCR-Motilin Receptor

Request The Product List ofMotilin Receptor Motilin Receptor

Motilin receptor is a G protein-coupled receptor that binds motilin. Motilin in turn is an intestinal peptide that stimulates contraction of gutsmooth muscle. The main function of motilin is to increase the migrating myoelectric complex component of gastrointestinal motility and stimulate the production of pepsin. Motilin is called "housekeeper of the gut" because it improves peristalsis in the small intestine and clears out the gut to prepare for the next meal. A high level of motilin secreted between meals into the blood stimulates the contraction of the fundus and antrum and accelerates gastric emptying. It then contracts the gallbladder and increases the squeeze pressure of the lower esophageal sphincter. Other functions of motilin include increasing the release of pancreatic polypeptide and somatostatin.

Cat. No. Product Name CAS No. Information
H3646

GSK962040 hydrochloride

 		923565-22-4

A potent, selective, small molecule motilin receptor agonist with pEC50 of 7.9 (hMTL-R); displays selectivity over closely related human ghrelin acceptor (pEC50< 6.0) and no liabilities at the hERG channel; possesses highly excellent pharmacokinetic profiles in both rat and dog.
H3645

GSK962040

 		923565-21-3

A potent, selective, small molecule motilin receptor agonist with pEC50 of 7.9 (hMTL-R); displays selectivity over closely related human ghrelin acceptor (pEC50< 6.0) and no liabilities at the hERG channel; possesses highly excellent pharmacokinetic profiles in both rat and dog.

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