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AAI-101 (AAI 101;AAI101;Enmetazobactam) Catalog No. H1008

AAI-101

CAS No.: 1001404-83-6

AAI-101(AAI 101;AAI101;Enmetazobactam)

Catalog No.: H1008

AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases

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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases; is currently in clinical development as a combination with cefepime, reduces the MIC50 of cefepime against a collection of 223 cefepime-nonsusceptible isolates of the family Enterobacteriaceae from >64 mg/L to 0.125 mg/L.

References

1. Crandon JL, et al. Antimicrob Agents Chemother. 2015 May;59(5):2688-94.

2. Crandon JL, et al. Pathogens. 2015 Aug 18;4(3):620-5.

Clinical Information

Bacterial Infection
Phase 1 Clinical

Physicochemical Properties

M.Wt 314.32
Formula C11H14N4O5S
CAS No. 1001404-83-6
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Chemical Name/SMILES (2S,3S,5R)-3-methyl-3-((1-methyl-1H-1,2,3-triazol-3-ium-3-yl)methyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

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Bacterial Bacterial Infection
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