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CCG 102487 (CCG102487) Catalog No. H1036

CCG 102487

CAS No.: 353787-50-5

CCG 102487(CCG102487)

Catalog No.H1036

CCG 102487 is a CCG-2979 analog that reduces streptokinase (SK) activity with little inhibition of group A streptococcal (GAS) growth

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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

CCG 102487 is a CCG-2979 analog that reduces streptokinase (SK) activity with little inhibition of group A streptococcal (GAS) growth; alters the transcript level for key GAS virulence genes, including multiple adhesins (fibronectin binding proteins, collagen-like surface protein, laminin-binding surface protein, and M protein), cytolytic toxins (streptolysins O and S), secreted extracellular proteases (Mac, C5a peptidase, and SpeB), streptodornase Sda1 (DNase), complement inhibitor protein, and streptokinase.

References

1. Sun H, et al. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74.

Physicochemical Properties

M.Wt 428.594
Formula C27H28N2OS
CAS No. 353787-50-5
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Chemical Name/SMILES 2-benzylsulfanyl-3-prop-2-enylspiro[6H-benzo[h]quinazoline-5,1'-cyclohexane]-4-one

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