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LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) Catalog No. H1002

LASV inhibitor 3.3

CAS No.: 554438-52-7

LASV inhibitor 3.3(LAMP1 inhibitor 3.3)

Catalog No.: H1002

LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells

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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

LASV inhibitor 3.3 (LAMP1 inhibitor 3.3) is a specific inhibitor of Lassa fever virus (LASV, IC50=1.8 uM), inhibits LASV GP-mediated infection and cross-links to the LASV receptor, LAMP1, in cells; does not inhibits the GP-mediated infection of LCMV, LuJo virus (LUJV) or Junin virus (JUNV), Ebola virus (EBOV) or vesicular stomatitis virus (VSV); inhibits LAMP1 binding to LASV GP, which is cholesterol-dependent and sensitive to 3.3 inhibition; LASV inhibitor 3.3 is a competitive inhibitor of cholesterol binding to LAMP1.

References

1. Wang MK, et al. PLoS Pathog. 2018 Sep 28;14(9):e1007322.

2. PCT Int. Appl. (2013), WO 2013022550 A2 20130214.

Physicochemical Properties

M.Wt 471.645
Formula C30H37N3O2
CAS No. 554438-52-7
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Chemical Name/SMILES N-(2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl)adamantane-1-carboxamide

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