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You are here:Home-Inhibitors & Agonists-Antibiotics and Antivirals-Bacterial-M4284

M4284 (M-4284;M 4284) Catalog No. H1100

M4284

CAS No.: 1373346-85-0

M4284(M-4284;M 4284)

Catalog No.: H1100

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay

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Purity & Documentation Purity: 98% (HPLC) Select Batch:

Biological Activity

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay; reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota; reduces UTI89 levels in the gut and urinary tracts of mice.

References

1. Spaulding CN, et al. Nature. 2017 Jun 22;546(7659):528-532.

2. Jarvis C, et al. ChemMedChem. 2016 Feb 17;11(4):367-73.

3. Han Z, et al. J Med Chem. 2012 Apr 26;55(8):3945-59.

Physicochemical Properties

M.Wt 460.483
Formula C23H28N2O8
CAS No. 1373346-85-0
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Chemical Name/SMILES N3,N5,3'-trimethyl-4'-(((3S,4R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-[1,1'-biphenyl]-3,5-dicarboxamide

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Bacterial
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